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سابقه و هدف: گونه های داتورا منبع تهیه تروپان آکالوییدهایی چون آتروپین و فرم چپ گرد آن یعنی هیوسیامین می باشند. جنس داتورا دارای 10 تا 15 گونه می باشد، که گونه d.stramonium l. در برخی از منابع به عنوان گونه اندمیک کناره دریای مازندران شناخته شده است. علاوه بر گونه استرامونیوم، گونه ی d.innaxia mill نیز با فراوانی کم تر در شمال ایران پراکندگی دارد. که افتراق این دو گونه با توجه به خصایص مرفولوژی...
Chemical compounds containing the tropone structure (2,4,6-cycloheptatrien-1-one), in their molecule, called troponoids, characterized by a seven-membered ring, are distributed in some plants, bacteria and fungi, although they are relatively rare. ß-Thujaplicin (2-hydroxy-4-isopropyl-2,4,6-cycloheptatrien-1-one), also known as hinokitiol, is a natural compound found in several plants of the Cup...
There is an urgent need to develop new drug treatment strategies to control the global spread of drug-sensitive and multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis). The ß-lactam class of antibiotics is among the safest and most widely prescribed antibiotics, but they are not effective against M. tuberculosis due to intrinsic resistance. This study shows that 2-aminoimidazole (2...
Genetic and molecular studies have confirmed the central role of amyloid-ß production and fibrillation in the pathogenesis of Alzheimer’s disease (AD). However, the pathological pathways from amyloid-ß peptide oligomerization to the major pathological hallmarks of AD, such as neurofibrillary tangles, inflammation and loss of cholinergic neurons, are largely unknown. The innate immunity defence ...
A study by Keam et al demonstrated that influenza vaccination, regardless of timing during 3-week cytotoxic chemotherapy cycles, may provide seroprotection. The majority of patients in this study were women with either breast or lung cancer. In an earlier study of patients with colorectal cancer, influenza vaccination was found to result in fewer cases of influenza, fewer cases of pneumonia, an...
saffron essential oil has a pleasant aroma and medicinal activities. however, it is sensible into the environmental condition. therefore, it should be protected against unwanted changes during storage or processing. encapsulation is introduced as a process by which liable materials are protected from unwanted changes. in the present study, different ratios (0:100, 25:75, 50:50, 75:25, and 100:0...
Amelioration of cardiovascular risk through a high intake of dietary fibre was originally highlighted by Ancel Keys and colleagues in the Journal of Nutrition in 1960 (Keys et al. 1960). More than 45 years later there is a growing body of evidence supporting the association between intake of whole grains and decreased incidence of fatal and nonfatal CHD (Liu et al. 1999; Steffen et al. 2003; Je...
This study reports consumer reactions to the graphic health warnings selected by the Food and Drug Administration to be placed on cigarette packs in the United States. We recruited three sets of respondents for an experimental study from a national opt-in e-mail list sample: (i) current smokers aged 25 or older, (ii) young adult smokers aged 18-24 and (iii) youth aged 13-17 who are current smok...
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