Business Process Redesign (BPR) and Information Architecture (IA) have been recognized as high organizational priority agenda items in the 1990s. This paper provides tile premise for integrating these two critical issues. A model depicting the relationship between IA and BPR is presented. IA design and BPR share a common focus on business processes and, when properly conducted, IA design should...

We have formal verified a number of algorithms for evaluating transcendental functions in double-extended precision floating point arithmetic in the Intel IA-64 architecture. These algorithms are used in the Itanium processor to provide compatibility with IA-32 (x86) hardware transcendentals, and similar ones are used in mathematical software libraries. In this paper we describe in some depth ...

We showed that sera from normal subjects after antigenic challenge with intradermal PPD or Candida antigens or with subcutaneous tetanus vaccine contain a factor that blocks the binding of mouse monoclonal anti-Ia antibody to Ia-positive T cells or to B35 M cells, an Ia-positive human B cell line. The blocking activity appears 48 to 72 h after antigenic challenge and is gone by day 7. The appea...

IFN-gamma is known to induce expression of Ia antigens on a variety of cell types. In the present study, this activity of IFN-gamma has been analyzed with a panel of 36 melanoma cell lines, normal melanocytes, and 97 cell lines representing a range of other differentiation lineages. 55% of the melanoma cell lines express Ia antigens in a constitutive manner without IFN-gamma induction. Of the 1...

An association has been established between human Ia-like (Ia) antigenic determinants, expression during DNA synthesis on granulocyte-macrophage colony forming cells (CFU-GM) and the regulatory action of acidic isoferritins in vitro. Treatment of human bone marrow cells with monoclonal-anti-Ia-like (Ia) plus complement inhibited colony and cluster formation by approximately 50% but did not affe...

BACKGROUND AND PURPOSE Genetic factors are important determinants of intracranial aneurysm (IA). Recently, a multinational, genome-wide association study identified 3 loci associated with IA, located on 2q (rs700651), 8q (rs10958409), and 9p (rs1333040 and rs10757278). The aim of this study was to evaluate these associations. METHODS Familial and sporadic cases were investigated. Familial cas...

BACKGROUND HIV/AIDS pandemic brought into focus the importance of safe blood donor pool. AIMS To analyze true seroprevalence of HIV infection in our blood donors and devise an algorithm for donor recall avoiding unnecessary referrals to voluntary counseling and testing centre (VCTC). MATERIALS AND METHODS 39,784 blood units were screened for anti-HIV 1/2 using ELISA immunoassay (IA-1). Samp...