Male Hartley guinea pigs (10/group) were assigned either to a control diet (no drug treatment) or to diets containing 0.4, 2.2, or 7.3 mg/day of an ileal apical sodium-codependent bile acid transporter (ASBT) inhibitor, 1-[4-[4[(4R,5R)-3,3-dibutyl-7-(dimethylamino)-2,3,4,5-tetrahydro-4-hydroxy-1,1-dioxido-1-benzothiepin-5-yl]phenoxy]butyl]-4-aza-1-azoniabicyclo[2.2.2] octane methanesulfonate (S...

BACKGROUND The aim of the study was to contribute to our understanding of the mechanisms responsible for the resistance of breast cancer cells to taxanes. MATERIALS AND METHODS Cell cycle characteristics, DNA fragmentation, p53 and p21(WAF1/CIP1) expression, caspase-3 and caspase-9 activity, cytochrome c release from mitochondria during cell death induction by the taxanes paclitaxel and docet...

432 Patterns of Sensitization to Common Food and inhalant Allergens and Allergic Symptoms in Preschool Children Man Yong Han, MD. Pediatrics, CHA University College of Medicine, Seoul, South Korea. Background: The prevalence of sensitization to allergens and symptoms of allergic disease differ with regard to age, but the relationship is poorly understood. This study aimed to investigate the pat...

constituents from Chinese natural medicines, we have reported the isolation and absolute stereostructure elucidation of two megastigmanes, sarmentoic acid and sarmentol A, and six megastigmane glycosides, sedumosides A1, A2, A3, B, C, and D, from the whole plant of Sedum sarmentosum (Crassulaceae) together with eight known megastigmane constituents. As a continuation of the characterization stu...

We consider two–dimensional supersymmetric Toda theories based on the Lie superalgebrasA(n, n), D(n+1, n) and B(n, n) which admit a fermionic set of simple roots and a fermionic untwisted affine extension. In particular, we concentrate on two simple examples, the B(1, 1) and A(1, 1) theories. Both in the conformal and massive case we address the issue of quantum integrability by constructing th...