نتایج جستجو برای: نوترون درمانی با بور bnct
تعداد نتایج: 672948 فیلتر نتایج به سال:
PURPOSE To investigate the efficacy and safety of boron neutron capture therapy (BNCT) in the treatment of inoperable head-and-neck cancers that recur locally after conventional photon radiation therapy. METHODS AND MATERIALS In this prospective, single-center Phase I/II study, 30 patients with inoperable, locally recurred head-and-neck cancer (29 carcinomas and 1 sarcoma) were treated with B...
The purpose of this study was to assess the potential of boron neutron capture therapy (BNCT), with a 6-h infusion of the boron carrier l-boronophenylalanine as a fructose preparation (BPA-f), as first-line radiotherapy for newly diagnosed glioblastoma multiforme (GBM). Patient survival data from a Phase II study using BNCT were compared with retrospective data from the two arms of a Phase III ...
BACKGROUND Boron neutron capture therapy (BNCT) is a unique particle radiation therapy based on the nuclear capture reactions in boron-10. We developed a novel boron-10 containing sodium borocaptate (BSH) derivative, 1-amino-3-fluorocyclobutane-1-carboxylic acid (ACBC)-BSH. ACBC is a tumor selective synthetic amino acid. The purpose of this study was to assess the biodistribution of ACBC-BSH an...
زمینه و هدف: هدف این مطالعه بررسی اثر افزایش دوز تومور با حضور بور-10 و گادولینیوم-157 و نانو ذرّات آنها در پرتودرمانی به روش شکار نوترونی به روش مونت کارلو می باشد. مواد و روش ها: یک چشمه کالیفرنیوم-252 مدل AT با استفاده از کد مونت کارلو MCNPX شبیهسازی شد و پارامترهای دوزیمتری آن محاسبه و با سایر مطالعات مقایسه شد. از چشمه کالیفرنیوم-252 به عنوان چشمه نوترون استفاده شد و افزایش دوز در داخل ت...
The treatment of malignant brain tumors using conventional therapies and surgery often leads to tumor recurrence and/or unwanted side effects. Boron neutron capture therapy (BNCT) is a binary and localized form of treatment for brain tumors and other difficult-to-treat cancers that uses nontoxic boron-containing agents. Boronated porphyrins and derivatives constitute a class of highly promising...
A multi-functional mesoporous silica nanoparticle (MSN)-based boron neutron capture therapy (BNCT) agent, designated as T-Gal-B-Cy3@MSN, was synthesized with hydrophobic mesopores for incorporating a large amount of o-carborane (almost 60% (w/w) boron atoms per MSN), and the amines on the external surface were conjugated with trivalent galactosyl ligands and fluorescent dyes for cell targeting ...
This study aimed to evaluate the residual radioactivity in mice induced by neutron irradiation with an accelerator-based boron neutron capture therapy (BNCT) system using a solid Li target. The radionuclides and their activities were evaluated using a high-purity germanium (HP-Ge) detector. The saturated radioactivity of the irradiated mouse was estimated to assess the radiation protection need...
Boron Neutron Capture Therapy (BNCT) is a binary radiation treatment modality based on nuclear reactions between thermal neutrons and stable isotope B concentrated primarily in cancer cells. It allows for delivery of high linear energy transfer (LET) radiation ( particles and Li nuclei) to tumors at the cellular level whilst avoiding unnecessary dose deposition to healthy tissue. Until now, mos...
روش تجزیه به طریق فعال سازی با نوترون یک روش آنالیز با حساسیت بالا است که دارای مزیت های متعددی نسبت به سایر روش های تجزیه می باشد. عدم نیاز به آماده سازی نمونه و انجام پذیر بودن آنالیز با داشتن مقدار کمی از نمونه مورد بررسی و غیر تخریبی بودن و بسیاری از مزایای دیگر، سبب شده اند که این روش در آنالیزهای مختلف بسیار مورد استفاده قرار گیرد. یکی از کاربردهای آن در آنالیز مواد غذایی است و همان طور ک...
We report a case of a benign notochordal cell tumor (BNCT) of the sacrum with atypical imaging features, which was incidentally discovered in a 74-year-old man undergoing evaluation for progressively worsening hip and back pain. It is important for radiologists, pathologists and orthopedic surgeons to be aware of the diagnosis of BNCT and be familiar with its radiographic features to avoid unne...
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