Hepatocellular carcinoma (HCC) is a severe liver malignancy with few drug treatment options. In finding an effective treatment for HCC, screening drugs that are already FDA-approved will fast track the clinical trial and drug approval process. Connectivity Map (CMap), a large repository of chemical-induced gene expression profiles, provides the opportunity to analyze drug properties on the basi...

INTRODUCTION We sought to investigate the reliability of a new electrodiagnostic method for identifying Electrodiagnosis of Brachial Plexus & Vessel Compression Syndrome (BPVCS) in rats that involves the application of transcranial electrical stimulation motor evoked potentials (TES-MEPs) combined with peripheral nerve stimulation compound muscle action potentials (PNS-CMAPs). RESULTS The lat...

PURPOSE The purpose of the present study was to investigate whether electrical stimulation (ES) improves the paralytic effect of botulinum toxin type A (BTX-A) and evaluate the differences between low frequency (LF) and high frequency (HF) ES in children with spastic diplegic cerebral palsy (CP). MATERIALS AND METHODS Twenty-three children with spastic diplegia CP who had BTX-A injections int...

We describe our Connection Management Access Protocol (CMAP) for managing multipoint connections in highspeed packet switched networks. A multipoint connection is a communication channel between two or more clients of the network, where all data sent by one client is received by all other clients. A point-to-point connection is a special case of a multipoint connection involving only two client...

The purpose of Project Pioneer is to develop an exploratory robot capable of creating a three-dimensional photo-realistic map of the inside of the damaged Chornobyl Nuclear Reactor, measure the environmental and radioactive conditions, and collect samples of concrete from the physical structure to determine its mechanical stability. This paper describes the Virtual Reality interface for Pioneer...

Large-scale cancer datasets such as The Cancer Genome Atlas (TCGA) allow researchers to profile tumors based on awide range of clinical andmolecular characteristics. Subsequently, TCGA-derived gene expression profiles can be analyzed with the Connectivity Map (CMap) to find candidate drugs to target tumors with specific clinical phenotypes or molecular characteristics. This represents a powerfu...

The postdoc position will be associated with the Computer Science Laboratory at Ecole Polytechnique (LIX) and will be supervised by Dominique Rossin, Eric Goubault, Samuel Mimram and Emmanuel Haucourt. The lab is composed of about a hundred researchers, and is associated with CNRS and INRIA through joint research projects. Ecole Polytechnique is one of the most famous engineering schools in Fra...

A new surface technique for the conduction study of the lower intercostal nerves has been developed and applied to 30 normal subjects. The problem of the short available nerve segment of the intercostal nerves and the bizzare compound motor action potential (CMAP) of inconsistent latency while recording over the intercostal muscles, is overcome by applying recording electrodes over the rectus a...

We have reported that an extract of Scutellaria baicalensis (ESB) has effects against obesity and hypertriglyceridemia in type 2 diabetic animal model (db/db mouse). In the present study, we tried to explain the pharmacological effects of ESB by integrating gene expression information from db/db mouse liver with that of ESB-treated HepG2 hepatocellular carcinoma cells. Using Connectivity Map (c...

UNLABELLED Genetic linkage mapping enables the study of genome organization and the association of heritable traits with regions of sequenced genomes. Comparative genetic mapping is particularly powerful as it allows translation of information between related genomes and gives an insight into genome evolution. A common tool for the storage, comparison and visualization of genetic maps is CMap. ...