Colistin, administered intravenously as its inactive prodrug colistin methanesulfonate (CMS), is increasingly used as last-line therapy to combat multidrug-resistant Gram-negative bacteria. CMS dosing needs to be adjusted for renal function. The impact of continuous ambulatory peritoneal dialysis (CAPD) on the pharmacokinetics of both CMS and colistin has not been studied. No CMS dosing recomme...

This document gives a comprehensive overview of the data grid system that CMS intends to operate around December 2003. This CMS data grid system will support both CMS production and analysis and will seamlessly tie together resources at CERN and at international CMS regional centers. This document focuses on the relation between the CMS software components and the grid software components opera...

Some properties of a 90% C2H2F4 gas mixture, used to operate resistive plate chambers in avalanche mode, are determined by comparing the experimental results with the prediction of simple analytical calculations. The fast charge distribution of the signal induced on pick-up electrodes is reproduced by means of a Monte Carlo simulation of the avalanche development. In addition predictions for a ...

Genes involved in the fenility restoration (llf) ofwild-abortive (WA)-type cytoplasmic male sterility (CMS) in rice have not been clearly identified, because of the inconsistency of their number and map position, Although the IILI genes, which restore Chinsurah Boro (BT)-type CMS, have been recently isolated, their efi fects on WA-type CMS are still unclear, In the present study, near-isogenic ...

In order to effectively manage organizational information assets, more and more organizations are beginning to implement content management systems (CMS) to consolidate multiple information sources into a single, centralized repository. While organizations implement CMS in attempts to help employees easily identify information sources and quickly locate relevant organizational documents, prior ...

This thesis presents studies related to track-based alignment for the future CMS experiment at CERN. Excellent geometric alignment is crucial to fully benefit from the outstanding resolution of individual sensors. The large number of sensors makes it difficult in CMS to utilize computationally demanding alignment algorithms. A computationally light alignment algorithm, called the Hits and Impac...

Mouse (m) and human embryonic stem cell-derived cardiomyocytes (hESC-CMs) are known to exhibit immature Ca(2+) dynamics such as small whole-cell peak amplitude and slower kinetics relative to those of adult. In this study, we examined the maturity and efficiency of Ca(2+)-induced Ca(2+) release in m and hESC-CMs, the presence of transverse (t) tubules and its effects on the regional Ca(2+) dyna...

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau...

The Model-Driven Engineering paradigm has become increasingly popular due to its advocation of using models as first-class citizens in the software development process, while artifacts such as documentation and source-code can be produced from those models by using automated transformations. On the other hand, we are currently witnessing the rise in popularity of a particular kind of web-applic...