نتایج جستجو برای: مسیر ras

تعداد نتایج: 54191  

2015
Howard Donninger Diego F. Calvisi Thibaut Barnoud Jennifer Clark M. Lee Schmidt Michele D. Vos Geoffrey J. Clark

The Ras oncoprotein is a key driver of cancer. However, Ras also provokes senescence, which serves as a major barrier to Ras-driven transformation. Ras senescence pathways remain poorly characterized. NORE1A is a novel Ras effector that serves as a tumor suppressor. It is frequently inactivated in tumors. We show that NORE1A is a powerful Ras senescence effector and that down-regulation of NORE...

Journal: :Cell 2015
Man-Tzu Wang Matthew Holderfield Jacqueline Galeas Reyno Delrosario Minh D. To Allan Balmain Frank McCormick

K-Ras and H-Ras share identical effectors and have similar properties; however, the high degree of tumor-type specificity associated with K-Ras and H-Ras mutations suggests that they have unique roles in oncogenesis. Here, we report that oncogenic K-Ras, but not H-Ras, suppresses non-canonical Wnt/Ca(2+) signaling, an effect that contributes strongly to its tumorigenic properties. K-Ras does th...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2012
Rajesh Kumar Qian Chen Yong Candice M Thomas Kenneth M Baker

The renin-angiotensin system (RAS) has mainly been categorized as a circulating and a local tissue RAS. A new component of the local system, known as the intracellular RAS, has recently been described. The intracellular RAS is defined as synthesis and action of ANG II intracellularly. This RAS appears to differ from the circulating and the local RAS, in terms of components and the mechanism of ...

Journal: :Cell 2005
Ingrid G.M. Kolfschoten Bart van Leeuwen Katrien Berns Jasper Mullenders Roderick L. Beijersbergen Rene Bernards P. Mathijs Voorhoeve Reuven Agami

Activating mutations of RAS frequently occur in subsets of human cancers, indicating that RAS activation is important for tumorigenesis. However, a large proportion of these cancers still retain wild-type RAS alleles, suggesting that either the RAS pathway is activated in a distinct manner or another pathway is deregulated. To uncover novel tumor-suppressor genes, we screened an RNA-interferenc...

الناز اسدی نیا, فاطمه وجودی مهربانی میرعلی محمدی

در میان پیشرفت­های روزافزون انسانی، فعالیت­هایی نظیر احداث پل‌ها، نقش قابل‌توجهی بر رفتار هیدرولیکی رودخانه‌ها، بعنوان منبع اصلی حیات، دارند. در تحقیق حاضر، با تعریف چهار سناریو،به بررسی تأثیر پل­های احداث شده بر رفتار هیدرولیکی رودخانه شهرچای ارومیه، با استفاده از هوش مصنوعی (GEP) و تلفیق نرم­افزارهای HEC-RAS و HEC-GEORAS پرداخته می­شود. در سناریو اول مشاهده می­گردد که وجود یا عدم وجود سازه­ها...

Journal: :Sao Paulo medical journal = Revista paulista de medicina 1999
C M Coutinho A S Bassini L G Gutiérrez O Butugan L P Kowalski M M Brentani M A Nagai

CONTEXT Ras gene mutations have been associated to a wide range of human solid tumors. Members of the ras gene family (Ki-ras, Ha-ras and N-ras) are structurally related and code for a protein (p21) known to play an important role in the regulation of normal signal transduction and cell growth. The frequency of ras mutations is different from one type of tumor to another, suggesting that point ...

2016
Maria Francesca Baietti Michal Simicek Layka Abbasi Asbagh Enrico Radaelli Sam Lievens Jonathan Crowther Mikhail Steklov Vasily N Aushev David Martínez García Jan Tavernier Anna A Sablina

Activation of the RAS oncogenic pathway, frequently ensuing from mutations in RAS genes, is a common event in human cancer. Recent reports demonstrate that reversible ubiquitination of RAS GTPases dramatically affects their activity, suggesting that enzymes involved in regulating RAS ubiquitination may contribute to malignant transformation. Here, we identified the de-ubiquitinase OTUB1 as a ne...

Journal: :Cancer research 2003
Masahito Tarutani Ti Cai Maya Dajee Paul A Khavari

Ras effects vary with developmental setting, with oncogenic RAS activation implicated in epithelial carcinogenesis. In epidermal cells, previous studies described conflicting Ras impacts on growth and differentiation, with the only in vivo studies relying on constitutive alterations of Ras function throughout development. To study Ras effects in developmentally mature adult epidermis, we expres...

Journal: :Journal of experimental & clinical cancer research : CR 2006
S J Plowman R L Berry S A Bader F Luo M J Arends D J Harrison M L Hooper C E Patek

Ras activating mutations result in constitutive activation of Ras signalling pathways and occur in 30% of human malignancies. K-ras encodes two splice variants, K-ras 4A and 4B, and K-ras activating mutations which jointly affect both isoforms are prevalent in lung, pancreatic and colorectal cancers. Using RT-PCR we examined their expression in normal adult human tissues and addressed whether K...

Journal: :The Journal of Cell Biology 2002
Hagit Niv Orit Gutman Yoel Kloog Yoav I. Henis

Ras-membrane interactions play important roles in signaling and oncogenesis. H-Ras and K-Ras have nonidentical membrane anchoring moieties that can direct them to different membrane compartments. Ras-lipid raft interactions were reported, but recent studies suggest that activated K-Ras and H-Ras are not raft resident. However, specific interactions of activated Ras proteins with nonraft sites, ...

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