PURPOSE This study was designed to evaluate the in vitro cytotoxicity and in vivo efficacy of TRA-8, a mouse monoclonal antibody that binds to the DR5 death receptor for tumor necrosis factor-related apoptosis-inducing ligand (also called Apo2L), alone and in combination with CPT-11, against human colon cancer cells and xenografts. EXPERIMENTAL DESIGN DR5 expression was assessed on human colo...

Large-scale mobile trac analytics is becoming essential to digital infrastructure provisioning, public transportation, events planning, and other domains. Monitoring city-wide mobile trac is however a complex and costly process that relies on dedicated probes. Some of these probes have limited precision or coverage, others gather tens of gigabytes of logs daily, which independently o‚er limit...

Accurate yet simple methods for tra c engineering are important for e cient management of resources in broadband networks. The goal of this paper is to apply and evaluate large deviation techniques for tra c engineering. In particular, we employ the recently developed theory of e ective bandwidths, where the e ective bandwidth depends not only on the statistical characteristics of the tra c str...

The Caenorhabditis elegans hermaphrodite is essentially a female that produces sperm. In C. elegans, tra-2 promotes female fates and must be repressed to achieve hermaphrodite spermatogenesis. In an effort to learn how mating systems evolve, we have cloned tra-2 from C. remanei, the closest gonochoristic relative of C. elegans. We found its structure to be similar to that of Ce-tra-2 but its se...

The Air Tra c Flow Management (ATFM) service is designed to ensure an optimum ow of air tra c to or through areas within which tra c demand at times exceeds the available capacity of the Air Tra c Control (ATC) system. It protects air tra c control from overload situations which are potentially dangerous to the safety of air tra c. It also ensures the maximum utilization of ATC capacity in all ...

The dynamic and e cient usage of the resources is one of the fundamental aspects studied in the DIANA project [1]: at rst the tra c speci cation should re ects the real tra c demand, but, at the same time, optimise the resources requested. In applications, which uses RSVP, this can be reached with the introduction of the RVBR Service described in [2], which is based on the renegotiation of the ...

Drug trade-related violence has escalated dramatically in Mexico since 2007, and recent years have also witnessed large-scale e↵orts to combat tra cking, spearheaded by Mexico’s conservative PAN party. This study examines the direct and spillover e↵ects of Mexican policy towards the drug trade. Regression discontinuity estimates show that drug-related violence increases substantially after clos...

BACKGROUND Transradial approach (TRA) outweighed transfemoral approach (TFA) in acute coronary syndrome patients because the former has better short-term outcomes in high-volume percutaneous coronary intervention (PCI) centers. Our study was one of the limited studies specifically in comparing the short- and medium-term effects of TRA and those of TFA in patients undergoing elective PCIs. MET...

PURPOSE Activating extrinsic apoptotic pathways targeting death receptors (DR) using agonistic antibodies or TNF-related apoptosis-inducing ligand (TRAIL) is promising for cancer therapy. However, most pancreatic cancers are resistant to TRAIL therapy. The present studies aimed to identify combination therapies that enhance the efficacy of TRAIL therapy and to investigate the underlying mechani...