Patients with NPM1-mutated AML M5 who develop spontaneous remission (SR) after antibiotic therapy at diagnosis seem to form a favorable prognosis and chemo sensitive subtype. We report three cases of AML M5 patients with the same genotype that experienced transient SR and are now leukemia free after standard treatment.

A xenogeneic rat anti-mouse la monoclonal antibody, M5/114 ( y P b , ~ ) , was studied for its effects in vitro on T cell proliferative responses. Strain distribution studies revealed that M5/114 could inhibit I-A subregion-restricted T cell responses of the H-2btd.qtU but not the H2'-**" haplotypes, indicating that this xenoantibody recognizes a polymorphic determinant on mouse la molecules....

T-cell molecular mimicry between streptococcal and heart proteins has been proposed as the triggering factor leading to autoimmunity in rheumatic heart disease (RHD). We searched for immunodominant T-cell M5 epitopes among RHD patients with defined clinical outcomes and compared the T-cell reactivities of peripheral blood and intralesional T cells from patients with severe RHD. The role of HLA ...

Deep Hubble Space Telescope (HST) photometry has recently been presented for the outer-halo globular clusters Palomar 4 and Eridanus. The new high-precision color-magnitude diagrams obtained for these globulars have allowed a measurement of their ages relative to M5 (NGC 5904), which is a wellobserved, much closer cluster. Assuming that the globular clusters share the same chemical composition,...

We study the worldvolume supersymmetric gauge theory of Mbranes probing backgrounds corresponding to wrapped M5-branes. In the case of M5-branes wrapping a 2-cycle in C2, we use M2-brane probes to compute the BPS spectra of the corresponding N = 2 gauge theory as well as M5-brane probes to calculate field theory parameters such as the gauge coupling, theta angle and complex scalar moduli space ...

In the Berkooz-Douglas matrix model of M theory in the presence of longitudinal M5-brane, we investigate the effective dynamics of the system by considering the longitudinal M5-brane as the background and the spherical M5-brane related with the other space dimensions as the probe brane. Due to there exists the background field strength provided by the source of the longitudinal M5-brane, an ope...

In this study a synthetic analog of the calmodulin-binding domain of myosin light chain kinase, a 17-amino-acid peptide (M5) was used to examine the possible role of calmodulin in melanotropin receptor function. Binding of beta-melanocyte-stimulating hormone to its membrane receptor and subsequent stimulation of adenylate cyclase (AC) were found to be specifically inhibited by M5 in a dose-depe...

We have used a set of overlapping chemically synthesized peptides representing the amino terminus of type 5 streptococcal M protein to localize protective, as opposed to nonprotective and tissue-crossreactive epitopes that might be appropriate for vaccine formulations. Rabbit antisera raised against SM5(1-35) reacted in high titer with pep M5 by ELISA and opsonized type 5 streptococci. None of ...

BACKGROUND In myeloid blasts, the expression and release of the multifunctional chemokine IL-8 could be expected to be differentiation-associated. METHODS We investigated the profile of interleukin-8 (IL-8) expression and release by leukemic cells obtained at diagnosis from 42 untreated adult patients with acute myeloid leukemia of various FAB subtypes (2 M0, 7 M1, 6 M2, 6 M3, 10 M4 and 11 M5...