Focal cortical dysplasia (FCD) is one of the most common epileptogenic lesions associated with development malformations. However, accurate detection FCD relies on radiologist professionalism, and in many cases, lesion could be missed. In this work, we solve problem automatic identification magnetic resonance images (MRI). For task, improve recent methods Deep Learning-based apply it for a data...

Failure to detect FCD and similar lesions encountered in patients with tuberous sclerosis can have significant clinical consequences, such as preventing surgical intervention for medically refractory epilepsy and misguiding prognostic information regarding cognitive development. Here, we show the beneficial effects on detection of FCD and cortical tubers when using a magnetization transfer T1 s...

OBJECTIVES To assess risk of a first clinical diagnosis of CNS demyelination (FCD) in relation to measures of Epstein-Barr virus (EBV) infection within the context of other known risk factors. METHODS This was a multicenter incident case-control study. FCD cases (n = 282) aged 18-59 years and controls (n = 558, matched on age, sex, and region) were recruited from 4 Australian centers between ...

White matter lesions (WMLs) are frequently detected in elderly people. Previous structural and functional studies have demonstrated that WMLs are associated with cognitive and motor decline. However, the underlying mechanism of how WMLs lead to cognitive decline and motor disturbance remains unclear. We used functional connectivity density mapping (FCDM) to investigate changes in brain function...

Focal cortical dysplasia (FCD) is the main cause of epilepsy and can be automatically detected via magnetic resonance (MR) images. However, visual detection of lesions is time consuming and highly dependent on the doctor's personal knowledge and experience. In this paper, we propose a new framework for positive unanimous voting (PUV) to detect FCD lesions. Maps of gray matter thickness, gradien...

PURPOSE Identifying factors involved in the development of drug resistant epilepsy (DRE) remains a challenge. Candidate gene studies have shown modulation of resistance to drugs by various multidrug resistance proteins in DRE. However the resistance to drugs in DRE could be more complex and multifactorial involving molecules in different pharmacokinetic processes. In this study for the first ti...

Sensory systems rescale their response sensitivity upon adaptation according to simple strategies that recur in processes as diverse as single-cell signaling, neural network responses, and whole-organism perception. Here, we study response rescaling in Escherichia coli chemotaxis, where adaptation dynamically tunes the cells' motile response during searches for nutrients. Using in vivo fluoresc...

− In many patients, lesions of focal cortical dysplasia (FCD) may go unrecognized by standard radiological analysis. This is due to the fact that identification of many of these malformations on visual inspection of conventional MRI is difficult due to their subtlety and the complexity of the brain’s convolutions. Quantitative MR image processing methods have the potential to help identify lesi...

PURPOSE To identify the disease locus associated with autosomal dominant Fuchs corneal dystrophy (FCD) in a large family and to compare the progression of severity in families mapped to the FCD1 and FCD2 loci. METHODS Seventeen individuals in a large family were examined by slit lamp biomicroscopy. Blood samples were collected, DNA was extracted, and a genome-wide scan was performed with a mi...