OBJECTIVES To identify factors affecting doctors' engagement with the Safer Patients Initiative (SPI). DESIGN Qualitative interview study. SETTING Four organisations participating in phase 1 of the SPI programme, from four different geographical locations in the UK. PARTICIPANTS 34 staff members, comprising senior executive/management leads involved in the SPI programme, the principal SPI...

Fis, one of the most important nucleoid-associated proteins, functions as a global regulator of transcription in bacteria that has been comprehensively studied in Escherichia coli K12. Fis also influences the virulence of Salmonella enterica and pathogenic E. coli by regulating their virulence genes, however, the relevant mechanism is unclear. In this report, using combined RNA-seq and chromati...

Cuppoletti, John, Danuta H. Malinowska, Kirti P. Tewari, Qiu-ju Li, Ann M. Sherry, Myra L. Patchen, and Ryuji Ueno. SPI-0211 activates T84 cell chloride transport and recombinant human ClC-2 chloride currents. Am J Physiol Cell Physiol 287: C1173– C1183, 2004. First published June 22, 2004; doi:10.1152/ajpcell. 00528.2003.—The purpose of this study was to determine the mechanism of action of SP...

Retinoic acid receptors (RAR) belong to the same nuclear receptor superfamily as thyroid hormone receptors (TR) that were previously shown to be modulated by dietary soy protein isolate (SPI). This study has examined the effect of dietary SPI and isoflavones (ISF) on hepatic RAR gene expression and DNA binding activity. In Expt. 1, Sprague-Dawley rats were fed diets containing 20% casein or 20%...

Climate change has caused droughts to increase in frequency and severity worldwide, which attracted scientists create drought prediction models mitigate the impacts of droughts. One most important challenges addressing is developing accurate predict their discrete characteristics, i.e., occurrence, duration, severity. The current research examined performance several different machine learning ...

Salmonella pathogenicity island 7 (SPI-7) in Salmonella enterica serovar Typhi appears to be related to other genomic islands. Evidence suggests that SPI-7 is susceptible to spontaneous circularization, loss, and transposition. Here, we demonstrate that a region within SPI-7 has the ability to mobilize the small incQ plasmid R300B.

This paper presents the results of a study of how software process and software process improvement (SPI) is applied in actual practice in the software industry using the indigenous Irish software product industry as a test-bed. The study used the grounded theory methodology to produce a theory, grounded in the field data, that explains how software processes are formed and evolve and when and ...

Uracil-terminated telechelic sulfonated polyimides (SPI-U) were transformed into noncovalent network membranes through biocomplementary hydrogen bonding recognition in the presence of an adenine-based crosslinking agent. SPI-U membrane exhibited dramatically improved methanol permeability, oxidative stability, proton conductivity, and selectivity relative to those of the standard SPI.

A number of presumptive target genes for the Ets-family transcription factor PU.1 have been identified in the B cell lineage. However, the precise function of PU.1 in B cells has not been studied because targeted null mutation of the PU.1 gene results in a block to lymphomyeloid development at an early developmental stage. In this study, we take advantage of recently developed PU.1(-/-)Spi-B(-/...

Context Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to hypogonadism. Objective The primary outcome was change in total testosterone levels. The secondary outcomes were the changes in glycemia and cardio...