BACKGROUND Praziquantel (PZQ) is an effective pesticide against monogeneans. Its pharmacokinetics in fish may be affected by water environment and temperature. The present study was designed to compare the pharmacokinetics, tissue distribution, and elimination of PZQ in freshwater-acclimated grass carp and brackish water cultured grass carp. Plasma and tissue PZQ concentrations were determined ...

BACKGROUND Fish are vulnerable to stress from over-crowding during transportation and eugenol is the most common sedative used to minimize fish injury. The ADI value of 2.5 mg/kg is recommended by the Joint FAO/WHO Expert Committee on Food Additives. The aim of this work was to study the elimination kinetics of eugenol following exposure of grass carp to a eugenol bath in a simulated transporta...

Grass carp, Ctenopharyngodon idella, is the largest freshwater aquaculture fish species worldwide. However, its environmental impacts are increasingly controversial. In this paper, we considered production of a 1500 g commercial grass carp as an example, analyzed through life cycle assessment. The results showed that indicators global warming potential (GWP), acidification potential, eutrophica...

The G-protein-coupled receptor GPR84, activated by medium-chain fatty acids, primarily expressed in macrophages and microglia, is involved inflammatory responses retinal development mammals amphibians. However, our understanding of its structure, function, tissue expression, signaling pathways fish limited. In this study, we cloned characterized the coding sequence GPR84 (ciGPR84) grass carp. A...

BACKGROUND Myxovirus resistance (Mx) proteins are crucial effectors of the innate antiviral response against a wide range of viruses, mediated by the type I interferon (IFN-I) signaling pathway. However, the antiviral activity of Mx proteins is diverse and complicated in different species. METHODOLOGY/PRINCIPAL FINDINGS In the current study, two novel Mx genes (CiMx1 and CiMx3) were identifie...