The phosphatidyl inositol 3-kinase-like kinases (PIKKs), ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) regulate parallel damage response signalling pathways. ATM is reported to be activated by DNA double-strand breaks (DSBs), whereas ATR is recruited to single-stranded regions of DNA. Although the two pathways were considered to function independently, recent studies have ...

ATM protocols do not implement Hand-off functions that are required to support wireless users. Complementary Signaling solution is proposed to implement handoff functions in an ATM network context to support mobility of wireless users. Complementary Signaling uses switched ATM connections to encapsulate mobility related signaling messages between wireless-to-wire line inter-working nodes at the...

Ataxia telangiectasia patients, with constitutional bi-allelic ATM mutations, have a marked risk of lymphoid tumors and ATM mutation carriers have a smaller risk of cancer. Sporadic ATM mutations occur in 10-20% of chronic lymphocytic leukemia and are often associated with chromosome 11q deletions which cause loss of an ATM allele. The role of constitutional ATM mutations in the pathogenesis of...

Status of this Memo This memo provides information for the Internet community. It does not specify an Internet standard of any kind. Distribution of this memo is unlimited. Abstract This document specifies an ATM-based protocol for communication between ST2+ agents. The ST2+ over ATM protocol supports the matching of one hop in an ST2+ tree-structure stream with one ATM connection. In this docu...

Abstract Background Ataxia Telangiectasia Mutated (ATM) protein kinase is the major sensor of DNA damage response (DDR) and oxidative stress, variously implicated in cellular metabolism. Previous studies on ATM functions heart have produced conflicting results. Here we hypothesized that might regulate cardiomyocyte metabolic homeostasis function. Methods Atm-mutated mice (Atm-/-) their wild-typ...

the electrocatalysis of the oxygen reduction reaction (orr) on carbon supportedpt-v (1:1) catalyst in polymer electrolyte fuel cells (pefc) was investigated. atan oxygen pressure of one atm an enhanced electrocatalytic property of pt-v/ccompared with pt/c is revealed. these results indicate the occurrence of adifferent electrocatalytic mechanism for the orr on pt/c and pt-v/c. anincrease of mas...

This transparent cell transport service allows migration of ATM services to a PSN without having to provision the ATM subscriber or customer edge (CE) devices. The ATM CEs will view the ATM transparent cell transport service as if they were directly connected via a Time Division Multiplexer (TDM) leased line. This service is most likely to be used as an internal function in an ATM service provi...