Periodontal ligament-associated protein-1 (PLAP-1)/asporin is a recently identified novel member of the small leucine-rich repeat proteoglycan family. PLAP-1/asporin is involved in chondrogenesis, and its involvement in the pathogenesis of osteoarthritis has been suggested. We report that PLAP-1/asporin is also expressed specifically and predominantly in the periodontal ligament (PDL) and that ...

Nod-like receptors (NLRs) are cytosolic sensors for microbial molecules. Νucleotide-binding oligomerization domain (NOD)1 and NOD2 recognize the peptidoglycan derivatives, meso-diaminopimelic acid (meso-DAP) and muramyl dipeptide (MDP), respectively, and trigger host innate immune responses. In the present study, we examined the function of NOD1 a...

New porous double layer (PDL) transpiration cooling technologies can allow gas turbine entry temperatures to be increased beyond current limits towards higher engine efficiency. However, PDL systems require inclined film holes with stress concentration factors in excess of 3.8. Combination thermoelastic Finite Element (FE) analysis Neuber type local strain approaches gives similar cyclic range ...

Human periodontal ligament (PDL) cells obtained from extracted teeth are a potential cell source for tissue engineering. We previously reported that poly(2-methoxyethyl acrylate) (PMEA) is highly biocompatible with human blood cells. In this study, we investigated the adhesion, morphology, and proliferation of PDL cells on PMEA and other types of polymers to design an appropriate scaffold for t...

BACKGROUND AND OBJECTIVE In dermatology, the pulsed dye laser (PDL) is the therapeutic instrument of choice for treating most superficial cutaneous vascular lesions. In addition, clinical experience over the last decade allowed us to treat patients with an ever increasing number of non-vascular indications. The purpose of this report is to summarize and critically appraise the scientific eviden...

Increased angiogenesis and tumor-induced immune evasion are two mechanisms by which clear cell renal cell carcinoma (ccRCC) proliferate and metastasize; however, the relationship between these pathways in human ccRCC is poorly understood. We conducted a nested case–control study using 98 archived tumor samples from patients diagnosed with primary ccRCC between 1990 and 2006, half of which were ...

Over the past 10 years, Carnegie Mellon’s Parallel Data Lab (PDL) has established itself as academia’s premiere storage systems research center, consistently pushing the state-of-the-art with new storage system architectures, technologies, and design methodologies. Today, the PDL consists of over 40 active researchers and has an annual budget of over $2.5 million. As we prepare for the 10th Ann...

We introduce a multi-type display calculus for Propositional Dynamic Logic (PDL). This calculus is complete w.r.t. PDL, and enjoys Belnap-style cut-elimination and subformula property.

objective: this study was designed to compare the stress produced at the pdl of abutment teeth with two angles of cervical convergence, in otherwise similar settings. materials and methods: two finite element models were designed for a second premolar and a removable partial denture frame containing an i-bar clasp. maximum principal stress (s1) and von mises stress (seqv) were assessed along a ...