Nitric oxide (NO) and protein S-nitrosylation (SNO) have been shown to play important roles in ischaemic preconditioning (IPC)-induced acute cardioprotection. The majority of proteins that show increased SNO following IPC are localized to the mitochondria, and our recent studies suggest that caveolae transduce acute NO/SNO cardioprotective signalling in IPC hearts. Due to the close association ...

This paper describes object-oriented (OO) techniques for encapsulating OS interprocess communication (IPC) mechanisms with C++ wrappers. The paper focuses on the C++ wrappers provided by the IPC SAP components in the ACE framework [2]. ACE is a collection of reusable C++ class libraries and OO framework components that simplify the development of portable, high-performance and real-time communi...

The hippocampal CA1 region is sensitive to hypoxic and ischemic injury but can be protected by ischemic preconditioning (IPC). However, the mechanism through which IPC protects hippocampal CA1 neurons is still under investigation. Additionally, the role of autophagy in determining the fate of hippocampal neurons is unclear. Here, we examined whether IPC induced autophagy to alleviate hippocampa...

The IPC chronic classification development process started with the preparation of the IPC Manual version 2.0. Since the main focus of IPC has been on classification of acute food insecurity, refining tools for the acute analysis was also the main priority in the new version of the Manual. Draft tools for analyzing chronic food insecurity were included in the Annex of the Manual, and IPC users ...

Transmissible gastroenteritis virus (TGEV) infection of piglets results in a very rapid and massive release of IFN-alpha in serum and secretions. The objective of this work was to characterize the IFN-alpha-producing cells (IPC) in tissues of TGEV-infected piglets. Caesarean-derived colostrum-deprived piglets were infected orally with the TGEV virulent Miller strain and IPC were characterized i...

AIMS While a wealth of data has uncovered distinct microRNA (miR) expression alterations in hypertrophic and ischaemic/reperfused (I/R) hearts, little is known about miR regulation and response to ischaemic preconditioning (IPC). METHODS AND RESULTS We analysed miRs in murine hearts preconditioned with six cycles of 4 min ischaemia via coronary artery occlusion, followed by 4 min reperfusion ...

BACKGROUND Accumulating evidence pinpoints to the pivotal role of mitogen-activated protein kinases (MAPKs) in the signal transduction underlying cardiac preconditioning. METHODS PD98059, an inhibitor of extracellular signal-regulated protein kinase (MEK-ERK1/2), and SB203580, an inhibitor of p38 MAPK, were used to evaluate the role of MAPKs with respect to postischemic functional recovery in...

objective(s): in the present study, we investigated the effect of ischemic preconditioning (ipc) on c-myb immunoreactivity as well as neuronal damage/death after a subsequent lethal transient ischemia in gerbils. materials and methods: ipc was subjected to a 2 min sublethal ischemia and a lethal transient ischemia was given 5 min transient ischemia. the animals in all of the groups were given r...

Clinical records of 94 chronic venous ulcer patients (treated at two independent specialty centers) were included in a retrospective analysis to evaluate the effects of standard of care, plus continued intermittent pneumatic compression (IPC) therapy during and after wound closure. Both clinical centers employed the Venous Clinical Severity Score (VCSS) to monitor clinical outcomes. IPC applica...

AIMS The aims of this study were to determine whether chronic oestrogen withdrawal influences the development of ischaemic preconditioning (IPC) in female hearts, to investigate the mechanism whereby IPC is impaired, and to assess whether direct activation of protein kinase C (PKC) can mimic IPC in female hearts with chronic oestrogen depletion. METHODS AND RESULTS We performed Sham-operation...