5,258,947 A * 1111993 Sourgen ...................... 365196 5,677,691 A * 1011997 Hosticka et al. .............. 326139 5,705,938 A * 111998 Kean ........................... 326139 5,959,871 A * 911999 Pierzchala et al. .......... 3271565 5,970,487 A * 1011999 Shackleford et al. ......... 706113 6,360,191 B1 * 312002 Koza et al. ................... 703114 6,363,517 B1 * 312002 Levi et al. ........

The mammalian nuclear lamina protein lamin B1 is posttranslationally modified by farnesylation, endoproteolysis, and carboxymethylation at a carboxyl-terminal CAAX motif. In this work, we demonstrate that the CAAX endoprotease Rce1 is required for lamin B1 endoproteolysis, demonstrate an independent pool of proteolyzed but nonmethylated lamin B1, as well as fully processed lamin B1, in interpha...

We report that a fatty acyl transferase, endophilin B1, is required for maintenance of mitochondrial morphology. Down-regulation of this protein or overexpression of endophilin B1 lacking the NH(2)-terminal lipid-modifying domain causes striking alterations of the mitochondrial distribution and morphology. Dissociation of the outer mitochondrial membrane compartment from that of the matrix, and...

Abstract. Let B1 be the unit open disk in R2 and M be a closed Riemannian manifold. In this note, we first prove the uniqueness for weak solutions of the harmonic map heat flow in H1([0, T ]×B1,M) whose energy is non-increasing in time, given initial data u0 ∈ H(B1,M) and boundary data γ = u0|∂B1 . Previously, this uniqueness result was obtained by Rivière (when M is the round sphere and the en...

Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Self-assembling peptide hydrogels were modified to deliver transforming growth factor b1 (TGF-b1) to encapsulated b...

b-Blockers are widely used for hypertension treatment but must be taken daily. We have developed a novel b-blocker by targeting b1-adrenergic receptor (b1-AR) mRNA with antisense oligodeoxynucleotides (b1-ASODN). A single intravenous injection of b1-AS-ODN significantly reduced cardiac contractility and blood pressure (3865 mm Hg, P,0.05) in spontaneously hypertensive rats for 3 weeks. In the p...

Let(b1, . . .,bn) be a lattice basis with Gram-Schmidt orthogonalization(b1, . . . ,b∗n), the quantities‖b1‖/‖bi ‖for i = 1, . . . , n play important roles in analyzing lattice reduction algorithms and lattice enumeration algorithms.In this paper, we study the problem of minimizing the quantity‖b1‖/‖bn‖ over all bases(b1, . . .,bn) of a givenn...

Semaphorins are axon guidance molecules that signal through the plexin family of receptors. Semaphorins also play a role in other processes such as immune regulation and tumorigenesis. However, the molecular signaling mechanisms downstream of plexin receptors have not been elucidated. Semaphorin 4D is the ligand for the plexin-B1 receptor and stimulation of the plexin-B1 receptor activates the ...

Mutations in the ephrin-B1 gene result in craniofrontonasal syndrome (CFNS) in humans, a congenital disorder that includes a wide range of craniofacial, skeletal, and neurological malformations. In addition to the ability of ephrin-B1 to forward signal through its cognate EphB tyrosine kinase receptors, ephrin-B1 can also act as a receptor and transduce a reverse signal by either PDZ-dependent ...

In the course of screening for novel anticancer compounds, B1 [N-(2-(dimethylamino)ethyl)-2-aminothiazonaphthalimide], a novel amonafide analogue, was generated as a new anticancer candidate. In the present study, B1 displayed stronger antitumor effects than amonafide in HL60 cells. We further examined whether B1 overcomes the resistance conferred by Bcl-2, as overcoming the resistance conferre...