BACKGROUND Translating research evidence into clinical practice (TRIP) is an important initiative for health services so that care delivered is cost-effective, is efficient, and improves patient outcomes. Most TRIP studies have reported on disseminating and implementing clinical practice guidelines, protocols, or care pathways and have been undertaken in acute rather than community settings. ...

We present a constraint programming formulation for the elevator trip origin-destination matrix estimation problem, and study different deterministic and randomized algorithms to solve the problem. An elevator trip consists of successive stops in one direction of travel with passengers inside the elevator. It can be defined as a directed network, where the nodes correspond to the stops on the t...

The primary objective of the National Airspace System (NAS) is the transportation of passengers and cargo. Since passenger trip time performance is positively correlated with passenger satisfaction, airfare elasticity, and airline profits, it follows that the National Air Space (NAS) performance evaluation, modernization, and consumer protection should be based on passenger trip performance. Pu...

The return trip often seems shorter than the outward trip even when the distance and actual time are identical. To date, studies on the return trip effect have failed to confirm its existence in a situation that is ecologically valid in terms of environment and duration. In addition, physiological influences as part of fundamental timing mechanisms in daily activities have not been investigated...

Epithelial-mesenchymal transition (EMT) is a process by which epithelial cells undergo conversion to a mesenchymal phenotype contributing to wound repair by fibrosis and to cancer cell acquisition of invasive ability. Recently, we showed that type II TGF-β receptor interacting protein-1 (TRIP-1), a protein identified as a phosphorylation target of the TGF-β type II receptor kinase and as a func...

In contrast to white adipose tissue, brown adipose tissue (BAT) is known to play critical roles for both basal and inducible energy expenditure. Obesity is associated with reduction of BAT function; however, it is not well understood how obesity promotes BAT dysfunction, especially at the molecular level. Here we show that the transcription regulator TRIP-Br2 mediates ER stress-induced inhibiti...

TANK-binding kinase 1 (TBK1) plays an essential role in Toll-like receptor (TLR)- and retinoic acid-inducible gene I (RIG-I)-mediated induction of type I interferon (IFN; IFN-α/β) and host antiviral responses. How TBK1 activity is negatively regulated remains largely unknown. We report that TNF receptor-associated factor (TRAF)-interacting protein (TRIP) promotes proteasomal degradation of TBK1...

This study aims to explore the trip fuel consumption from a large-scale dataset. To better understand how the multiple variables (e.g., average travel speed, trip distance) influence the trip fuel consumption, we propose the support vector machine (SVM) to learn the relationship between the trip fuel consumption and the corresponding factors. A large-scale GPS and CAN (Controller Area Network) ...

I/S Nordforbrænding is an inter-municipal waste management company located north of Copenhagen, the capital of Denmark, which serves approximately 180,000 inhabitants. It was founded in 1965 and it is owned by six municipalities in North Sealand: Allerød, Søllerød, Hørsholm, Fredensborg-Humlebæk, Karlebo and Helsingør as shown in Fig. 1. The company’s mission was to establish a Waste-to-Energy ...

One of the most important aims of each treatment planning system is the ability of delivering a target conformal dose distribution. Developed and successful used within the heavy ion therapy pilot project, the TReatment plannIng for Particles ( TRiP )[1] is characterised by the capability of delivering exact results in relatively short time, making it possible to rapidly verify and, if necessar...