نتایج جستجو برای: فعالیت ace
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Angiotensin-converting enzyme (ACE) is a membrane-anchored ectoprotein that is proteolytically cleaved, yielding an enzymatically active soluble ACE. Two mouse monoclonal antibodies, MAbs 1B3 and 5C8, were generated to the C-terminal part of human soluble ACE. MAb 1B3 recognized the catalytically active ACE, as revealed by ELISA and precipitation assays, whereas Western blotting and immunohisto...
BACKGROUND The present study was designed to explore the association of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D, rs4646994) polymorphism, plasma ACE activity, and circulating ACE mRNA expression with essential hypertension (EH) in a Chinese population. In addition, a new detection method for circulating ACE mRNA expression was explored. METHODS The research was approv...
The phosphorylation of the short C-terminal cytoplasmic domain of the somatic angiotensin-converting enzyme (ACE) is involved in the regulation of enzyme shedding. We determined whether the phosphorylation of the cytoplasmic domain of ACE (ACEct) on Ser1270 regulates the cleavage/secretion of the enzyme by affecting its association with other proteins. ACE was associated with beta-actin and the...
Article| July 2023 ACE Question ASA Monitor 2023, Vol. 87, 7. https://doi.org/10.1097/01.ASM.0000945056.15859.90 Views Icon Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Facebook Twitter LinkedIn Email Cite Get Permissions Search Site Citation Question. 2023; 87:7 doi: Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers En...
Angiotensin-converting enzyme (ACE) produces the vasoconstrictor angiotensin II. The ACE protein is composed of two homologous domains, each binding zinc and each independently catalytic. To assess the physiologic significance of the two ACE catalytic domains, we used gene targeting in mice to introduce two point mutations (H395K and H399K) that selectively inactivated the ACE N-terminal cataly...
سولفورموستارد (sm) و یا گاز خردل یک عامل آلکیله کننده با خواص سیتوتوکسیک، جهش زایی وتاول زایی است، که پوست، چشم و سیستم تنفسی را هدف قرار می دهد.sm به عنوان سلاح شیمیایی توسط نیروهای نظامی عراق علیه نیروهای رزمنده و شهروندان ایرانی مورد استفاده قرار گرفت. این عامل تعداد زیادی از ایرانی ها را مصدوم ساخت و بخش قابل توجهی از آنان هنوز هم از عوارض ناشی از خردل رنج می برند. تنوع ژنتیکی در ژن کد کنند...
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