Superantigens (SAg) are a family of bacterial and viral proteins with strong immunostimulatory properties. SAg bound to major histocompatibility complex (MHC) class II molecules activate a high frequency of T cells and represent the most potent known activators of T cells to date. To explore the use of SAg for T cell-based tumor therapy we have created a tumor-reactive SAg by engineering a fusi...

Elucidating the role of carbohydrate quality in human nutrition requires a greater understanding of how the physico-chemical characteristics of foods relate to their physiological properties. It was hypothesised that rapidly available glucose (RAG) and slowly available glucose (SAG), in vitro measures describing the rate of glucose release from foods, are the main determinants of glycaemic inde...

7 International Conference on Head-driven Phrase Structure Grammar, Berkeley 22 July 2000 Aims: 1⁄2 Supporting the ARG-ST / DEPS / VALENCE distinction 1⁄2 Working towards a theory of diathesis and diathetic paradigmatic relations in HPSG 1⁄2 Reconsidering phenomena that are sensitive to subject prominence 1⁄2 Possibilities of making compatible the insightful HPSG analyses of binding (Manning an...

The aim of this research work was to investigate on the ball filling estimation of Miduk semi-autogenous (SAG) Mill via an utilized method. Miduk copper concentrator is located in Kerman Province, Iran, and its size reduction stage includes one gyratory crusher which feeds one SAG mill (9.75 dia.(m)*3.88 length(m)) following two parallel ball mills (5dia.(m)*7lenght(m)). After SAG mill, a tromm...

After mouse mammary tumor virus (MMTV) infection, B lymphocytes present a superantigen (Sag) and receive help from the unlimited number of CD4(+) T cells expressing Sag-specific T-cell receptor Vbeta elements. The infected B cells divide and differentiate, similarly to what occurs in classical B-cell responses. The amplification of Sag-reactive T cells can be considered a primary immune respons...

semang (sag), a mutation isolated as a suppressor of Drosophila Src42A, has previously been shown to affect some receptor tyrosine kinase mediated embryonic processes. Here we show that sag specifically affects the development of R1, R6 and R7 photoreceptor cells in a cell-autonomous manner. These cells are absent in the mutant at the time when they normally appear in the ommatidial pre-cluster...

Power quality issues have been a source of major concern in recent years due to extensive use of power electronic devices and non-linear loads in electrical power system. In power systems the common disturbances are voltage sags and swells, usually associated with power system faults. Therefore the effective detection of voltage sags and swells event is an important issue for both voltage sag a...

Pentavalent antimony complexes, such as sodium stibogluconate and sodium antimony gluconate (SAG), are still the first choice for chemotherapy against various forms of leishmaniasis, including visceral leishmaniasis, or kala-azar. Although the requirement of a somewhat functional immune system for the antileishmanial action of antimony was reported previously, the cellular and molecular mechani...

Neuroblasts of the statoacoustic ganglion (SAG) initially form in the floor of the otic vesicle during a relatively brief developmental window. They soon delaminate and undergo a protracted phase of proliferation and migration (transit-amplification). Neuroblasts eventually differentiate and extend processes bi-directionally to synapse with hair cells in the inner ear and various targets in the...

Unlike immortalized cell lines, normal human fibroblasts in culture undergo replicative senescence in which the number of population doublings is limited. While fibroblasts display a variety of changes as they senesce in vitro, little is known about how gene expression varies as a function of population doubling level. We have used differential hybridization screening to identify human genes th...