A new corneal preserving medium (K-Sol), developed by Kaufman and others, contains purified chondroitin sulphate, TC 199, HEPES buffer, and gentamicin. Another new medium (JM) containing bicarbonate-free glucose-phosphate Ringer solution and dextran 70 has been developed in Japan. New Zealand white rabbit corneas with scleral rims were stored in each medium at 4 degrees C for one or two weeks. ...

This essay looks at the historical significance of three APS classic papers that are freely available online: Fernández C and Goldberg JM. Physiology of peripheral neurons innervating otolith organs of the squirrel monkey. I. Response to static tilts and to long-duration centrifugal force. J Neurophysiol 39: 970–984, 1976 (http://jn.physiology.org/cgi/ reprint/39/5/970). Fernández C and Goldber...

Despite the key role that pattern recognition receptors (PRRs) play in regulating immunity in plants and animals, the mechanism of activation of the associated non-arginine-aspartate (non-RD) kinases is unknown. The rice PRR XA21 recognizes the pathogen-associated molecular pattern, Ax21 (activator of XA21-mediated immunity). Here we show that the XA21 juxtamembrane (JM) domain is required for ...

Abnormalities of intestinal calcium absorption and the vitamin D axis in the spontaneously hypertensive rat (SHR) are controversial. The present report documents a reduction in circulating 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in the 12-14-wk-old male SHR with evidence of its functional significance. Both plasma 1,25(OH)2D3 and mucosa-to-serosa duodenal calcium flux (Jm-s), measured by the Uss...

Thermal radiosensitization was studied in two human I-cell acute lymphoblastic leukemia cell lines (JM and MOLT3) with regard to heatirradiation sequence and heating duration. In MOLT3 thermal radiosensitization was maximal when 43.5°C hyperthermia immediately preceded or followed irradiation; at 41.S°C, radiosensitization was maximal with hyperthermia immediately before or up to 3 h after ir...

Authors’ contributions C. elegans experiments were performed by VF, VD, CMR, PG, and CDL. Neuro 2a experiments were performed by GHS. Characterization of ADDL preps was performed by PTV. ADDL-binding and toxicity assays in hippocampal cultures were performed and analyzed by PNL, and Tau phosphorylation analysis done by ND, EYF and MAS. Adenovirus transfection of cortical neurons was performed b...

An analytical model based on a single-DOF is proposed for extracting the characteristic waveforms (CSCW) from the cardiac sounds recorded by an electric stethoscope. Also, the diagnostic parameters [T1, T2, T11, T12], the time intervals between the crossed points of the CSCW and an adaptive threshold line (THV), were verified useful for identification of heart disorders. The easy-understanding ...

We study the matter enhancement of T violation in neutrino oscillation with three generations. The magnitude of T violation is proportional to Jarlskog factor J . Recently, the elegant relation, (∆m)12(∆m)23(∆m)31Jm = ∆12∆23∆31J , is derived, where ∆ij = ∆m 2 ij/(2E) and the subscript m denotes the quantities in matter. Using this relation, we reconsider how Jm changes as the function of the ma...

Receptor tyrosine kinases exhibit a variety of activation mechanisms despite highly homologous catalytic domains. Such diversity arises through coupling of extracellular ligand-binding portions with highly variable intracellular sequences flanking the tyrosine kinase domain and specific patterns of autophosphorylation sites. Here, we show that the juxtamembrane (JM) segment enhances RET catalyt...

This study presents the impact of carbon nanotubes (CNTs) on mitochondrial oxygen mass flux (Jm) under three experimental conditions. New experimental results and a new methodology are reported for the first time and they are based on CNT Raman spectra star graph transform (spectral moments) and perturbation theory. The experimental measures of Jm showed that no tested CNT family can inhibit th...