Journal of Cell Science was alerted by readers to potential image manipulation and reuse in papers published in the journal by Dr Anil K. Jaiswal, the corresponding author. An investigation was conducted by the author’s institution, the University of Maryland, Baltimore, during which they documented alleged irregularities in Figures 3A, 3C, 5A, 7C, 8D and 9B of the paper named above. The invest...

In this work, we describe synthesis of conjugates of betulinic acid with substituted triazoles prepared via Huisgen 1,3-cycloaddition. All compounds contain free 28-COOH group. Allylic bromination of protected betulinic acid by NBS gave corresponding 30-bromoderivatives, their substitution with sodium azides produced 30-azidoderivatives and these azides were subjected to CuI catalysed Huisgen 1...

Hydroboration of allyl(dimesityl)phosphane with HB(C(6)F(5))(2) gives the intramolecular five-membered P-B Lewis pair 7, that was characterized by X-ray diffraction. Similarly, HB(C(6)F(5))(2) addition to the substrates (mesityl)(2)P-CR[double bond, length as m-dash]CH(2) (R = CH(3), Ph) yield the corresponding (mesityl)(2)P(micro-CHRCH(2))B(C(6)F(5))(2) products 9a (R = CH(3)) and 9b (R = Ph) ...

In this study, we aimed to determine VEGFR-2, EGFR and PDGFR-β tyrosine kinase inhibitory activities of some pyrrolo[2,3-d]pyrimidine derivatives previously synthesized and showed potent cytotoxic and apoptotic effects against several cancer cell lines by our group and to evaluate the relationships between inhibitory activities and binding properties of the active compounds by molecular docking...

A variety of photoluminescent, and in some cases thermochromic, metal-organic networks of CuCN were self-assembled in aqueous reactions with amine ligands: (CuCN) 2(Pip) ( 1a), (CuCN) 20(Pip) 7 ( 1b), (CuCN) 7(MePip) 2 ( 2), (CuCN) 2(Me 2Pip) ( 3a), (CuCN) 4(Me 2Pip) ( 3b), (CuCN) 7(EtPip) 2 ( 4), (CuCN) 4(Et 2Pip) ( 5), (CuCN) 3(BzPip) 2 ( 6a), (CuCN) 5(BzPip) 2 ( 6b), (CuCN) 7(BzPip) 2 ( 6c),...

On the Bacillus subtilis chromosome there are five examples of genes encoding two-component systems with response regulators of the OmpR family adjacent to genes encoding sub-family 9 ABC transport systems. Three of these (yts, yvc, yxd) are very similar in gene organization and in sequence. We demonstrate that the TCS and ABC transporter genes do not belong to the same transcriptional unit. Th...

The mechanism of the polar reaction between the superelectrophile PTAD (2) and diene (6b) in the presence of THF has theoretically been studied at the MPWB1K/6-311G** level. Our investigations reveal that this reaction takes place through a stepwise mechanism via formation of intermediate (7b) with a strong zwitterionic character. The first step of the reaction, which is associated with the nuc...