The pattern of actinomycin D-resistant RNA synthesis was examined during primary infection of HeLa cells by virulent Edmonston measles virus and in two HeLa clones persistently infected by the same strain of virus. One of these clones, K11, produces infectious virus of low virulence for HeLa cells, and the other, K11A-HG-1, has thus far failed to yield infectious virus. The patterns of virus-sp...

This paper identifies the basic methodological issues involved in the sampling design of the third wave of Taiwan Educational Panel Survey (TEPS). Central to the design are three design questions (1) sampling of schools, (2) the sampling of panel members from the second wave of junior high students for two more waves of follow-up, and (3) sampling of classes within school. A systematic discussi...

Despite the high value that internet users place on privacy, they offer their personal information for low compensations. This behavior, known as the privacy paradox, has been explained by a stream of literature with different behavioral biases, and in particular with hyperbolic discounting. However, economics offers two possible reasons to discount payoffs—costs of waiting and hazard rates—whi...

Modification of proteins by the addition of lysine (K)-63-linked polyubiquitin (polyUb) chains is suggested to play important roles in a variety of cellular events, including DNA repair, signal transduction, and receptor endocytosis. However, identifying such modifications in living cells is complex and cumbersome. We have generated a monoclonal antibody (mAb) that specifically recognizes K63-l...

Let P be a set of n points in R, and k ≤ n an integer. A sphere σ is k-rich with respect to P if |σ ∩ P | ≥ k, and is η-nondegenerate, for a fixed fraction 0 < η < 1, if no circle γ ⊂ σ contains more than η|σ ∩ P | points of P . We improve the previous bound given in [1] on the number of k-rich η-nondegenerate spheres in 3space with respect to any set of n points inR, from O(n/k+n/k), which hol...

One of Coase’s central insights is that distinguishing between the generator and recipient of an externality is of limited value because externality problems are reciprocal. We reconsider the relevance of the identity of the generator in a model with non-contractible investment ex ante but frictionless bargaining over the externality ex post. In this framework, a party may distort its investmen...

Protein ubiquitination regulates many cellular processes via attachment of structurally and functionally distinct ubiquitin (Ub) chains. Several atypical chain types have remained poorly characterized because the enzymes mediating their assembly and receptors with specific binding properties have been elusive. We found that the human HECT E3 ligases UBE3C and AREL1 assemble K48/K29- and K11/K33...