نتایج جستجو برای: شکستگی دو رشته ای dsb

تعداد نتایج: 423872  

2017
Li-Ting Diao Chin-Chuan Chen Briana Dennehey Sangita Pal Pingping Wang Zie-Jie Shen Angela Deem Jessica K Tyler

The DNA damage checkpoint is activated in response to DNA double-strand breaks (DSBs). We had previously shown that chromatin assembly mediated by the histone chaperone Asf1 triggers inactivation of the DNA damage checkpoint in yeast after DSB repair, also called checkpoint recovery. Here we show that chromatin assembly factor 1 (CAF-1) also contributes to chromatin reassembly after DSB repair,...

2001
Michiko Watanabe

We examined whether fillers (filled pauses) in a Japanese lecture appeared more frequently after discourse segment boundaries (DSB) than after other sentence boundaries. Contrary to our hypothesis that fillers occur more often after DSB than after other sentence boundaries, the frequency of fillers in the first phrase after DSB did not differ statistically from that after other sentence boundar...

Journal: :eLife 2015
Cathleen M Lake Rachel J Nielsen Fengli Guo Jay R Unruh Brian D Slaughter R Scott Hawley

Meiotic recombination begins with the induction of programmed double-strand breaks (DSBs). In most organisms only a fraction of DSBs become crossovers. Here we report a novel meiotic gene, vilya, which encodes a protein with homology to Zip3-like proteins shown to determine DSB fate in other organisms. Vilya is required for meiotic DSB formation, perhaps as a consequence of its interaction with...

ژورنال: :جغرافیایی سرزمین 2006
سعید پیراسته

توسعه کارست (karstification ) از جمله پدیده های زمین شناسی است که به دلیل هوازدگی و یا فرسایش شیمیایی همراه آب در مواد حل می شود، همانند سنگ آهک، دولومیت، ژیبس یا نمک در نزدیک سطح زمین . توسعهکارست غالبا در مناطقی که پوشش عظیمی از سنگ آهک، درز و شکاف وجود دارد و مناطق مرطوب به وجود می آید.محدوده تاقدیس پابده لالی بخشی از رشته کوه زاگرس در جنوب غرب ایران جهت مطالعه ارتباط کارست وشکستگی های موجود...

2015
Chunmin Ge Lixiao Che Chunying Du Jianhua Zhang

BRUCE is implicated in the regulation of DNA double-strand break response to preserve genome stability. It acts as a scaffold to tether USP8 and BRIT1, together they form a nuclear BRUCE-USP8-BRIT1 complex, where BRUCE holds K63-ubiquitinated BRIT1 from access to DSB in unstressed cells. Following DSB induction, BRUCE promotes USP8 mediated deubiquitination of BRIT1, a prerequisite for BRIT1 to...

Journal: :Molecular and cellular biology 2007
Eun Yong Shim Soo Jin Hong Ji-Hyun Oum Yvonne Yanez Yu Zhang Sang Eun Lee

Repair of DNA double-strand breaks (DSBs) protects cells and organisms, as well as their genome integrity. Since DSB repair occurs in the context of chromatin, chromatin must be modified to prevent it from inhibiting DSB repair. Evidence supports the role of histone modifications and ATP-dependent chromatin remodeling in repair and signaling of chromosome DSBs. The key questions are, then, what...

Journal: : 2022

هدف: رشته مهندسی عمران از رشته‌های پرطرفدار می‌باشد که دانش‌آموختگان آن مسئولیت‌های زیادی در سازندگی و آبادانی کشور دارند بر همین اساس ضرورت دارد برنامه‌ درسی منجر به نتایج مطلوب گردد. راستا، هدف پژوهش حاضر، شناسایی برنامه کارشناسی ارزیابی وضعیت موجود ‌درسی این بعد بوده است.مواد روش‌ها: رویکرد تحقیق، ترکیبی اکتشافی متوالی نوع ابزارسازی است. روش تحقیق کیفی مطالعه، پدیدارشناسی بخش کمی پیمایشی حاض...

Journal: :Applied sciences 2023

This article concerns the application of FEM method for prediction stress and deformation states in workpiece during diamond sliding burnishing (DSB). An updated Lagrange (UL) description was used to describe phenomena at a typical incremental step. The strain rate are described by non-linear relationships without linearization. material parameters were estimated tensile tests determine charact...

Journal: :Nature Cell Biology 2009

Journal: :Genes & development 2013
Liisa Kauppi Marco Barchi Julian Lange Frédéric Baudat Maria Jasin Scott Keeney

Different organisms display widely different numbers of the programmed double-strand breaks (DSBs) that initiate meiotic recombination (e.g., hundreds per meiocyte in mice and humans vs. dozens in nematodes), but little is known about what drives these species-specific DSB set points or the regulatory pathways that control them. Here we examine male mice with a lowered dosage of SPO11, the meio...

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