the discovery of rNa interference (rNai) in 1998 sparked a revolution in rNa research (Fire et al, 1998). it also triggered a surge of investment from biotechnology companies and major pharmaceutical companies to develop new drugs and therapies that exploit this new mechanism of gene regulation. the commercial interest intensified in 2006 after andrew Fire and craig Mello received the Nobel pri...

NOVEL ROLE FOR PENDRIN IN ORCHESTRATING BICARBONATE SECRETION IN CFTR-EXPRESSING AIRWAY SEROUS CELLS James P Garnett, Emma Hickman, Rachel Burrows, Péter Hegyi, László Tiszlavicz, Alan W Cuthbert, Peying Fong and Michael A Gray Institute for Cell & Molecular Biosciences, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK.; Novartis Institutes for Biomedical Research (NIBR), Novartis Horsham...

S45 Fallenberg E.M.: Advisory Board; Bayer. Research/Grant Support; GE Healthcare, Siemens Healthcare, Bayer. Speaker; GE Healthcare, Siemens Healthcare, Bayer. Froehlich J.M.: Consultant; Guerbet. Frydrychowicz A.: Research/Grant Support; Scientific stipend Bracco Diagnostics. Other; The University of Wisconsin Madison receives research support from GE Healthcare. Fürst S.: Employee; B.W. Jako...

The incidence and prevalence of diabetes mellitus (DM) continue to grow dramatically throughout the world, due primarily to the increase in type 2 DM (T2DM). Although improvements in DM and hypertension management have reduced the proportion of diabetic individuals who develop chronic kidney disease (CKD) and progress to end-stage renal disease (ESRD), the sheer increase in people developing DM...

Protein-carbohydrate interactions are important for glycoprotein structure and function. Antibodies of the IgG class, with increasing significance as therapeutics, are glycosylated at a conserved site in the constant Fc region. We hypothesized that disruption of protein-carbohydrate interactions in the glycosylated domain of antibodies leads to the exposure of aggregation-prone motifs. Aggregat...

Conclusion. Vaccinated individuals were more likely than unvaccinated individuals to benefit from antiviral treatment. This finding warrants confirmation in other populations. Disclosures. A. S. Monto, sanofi pasteur: Grant Investigator, Research grant. Novartis: Consultant, Consulting fee. Protein Sciences: Consultant, Consulting fee. E. T. Martin, Pfizer: Scientific Advisor, Research grant. M...