Introduction: Cardiac arrhythmias, e.g. atrial fibrillation and ventricular tachycardia, are increasingly treated by electrophysiological (EP) interventions [1]. Applying MR for guiding these interventions offers advantages like 3D visualization of the cardiac soft tissue in relation to the catheter, visualization of the treatment effect and absence of ionizing radiation [2,3]. The step towards...

Ependymin, a prominent protein of the brain's extracellular fluid (ECF) was previously implicated in the consolidation of memory and in the activity-driven sharpening of the retinotectal projection. Because both these phenomena probably involve the growth and elaboration of appropriate synapses, we have tested whether ependymin can serve as a substrate for the growth of axons from goldfish reti...

We recently reported the development of several monoclonal antibodies (MoAbs) to native human erythropoietin (Ep). In the present study we have used the two antibodies with highest affinity to develop a two-sided or sandwich enzyme-linked immunosorbent assay (ELISA) to measure Ep in human serum. In this assay Ep is incubated in microtiter wells precoated with the first (IgE) anti-Ep antibody. A...

BACKGROUND Topical formulations of non-steroidal anti-inflammatory drugs (NSAIDs), in particular diclofenac (DI), have become popular for treating various acute and chronic painful inflammatory conditions. OBJECTIVE To perform a literature review of (1) the use of topical NSAIDs; (2) the pharmaceutical, pharmacokinetic and pharmacodynamic properties of a medicated plaster (patch) containing d...

The homeostatic function of prostaglandin E(2) (PGE(2)) is dependent on a balance of EP receptor-mediated events. A disruption in this balance may contribute to the progression of renal injury. Although PGE(2) excretion is elevated in diabetes, the expression of specific EP receptor subtypes has not been studied in the diabetic kidney. Therefore, the purpose of this study was to characterize th...

Some characteristics of the process by which endogenous pyrogen (EP), the mediator of fever, is released from cells were examined by using human blood leukocytes incubated in vitro. Studies were designed to examine a possible role for leukocyte products, including EP, in the induction, augmentation, or suppression of pyrogen release by blood leukocytes. Products of stimulated leukocytes, includ...

Conventional electroporation (EP) by 0.1 to 1 kV/cm pulses longer than 100 micros, and supra-electroporation by 10 to 300 kV/cm pulses shorter than 1 micros cause different cellular effects. Conventional EP delivers DNA, proteins, small drugs, and fluorescent indicators across the plasma membrane (PM) and causes moderate levels of phosphatidylserine (PS) translocation at the PM. We hypothesize ...

Ectopic pheochromocytoma (EP) is considered as pheochromocytoma located at extra-adrenal site. Surgical removal is believed to be the best choice for treatment of pheochromocytoma. We present a series EP resected by laparoscopic approach (LEP) and confirm its feasibility. We retrospectively reviewed clinical data of 4 patients underwent laparoscopic resection of LEP (periaortocaval EP, n = 1; r...

a thin film of epinephrine (ep) was electrochemically deposited on the surface of glassy carbon electrode previously activated in nahco3 solution. the cyclic voltammograms of the modified electrode indicate that the surface confined ep are strongly dependent on the solution ph, as expected for quinone/hydroquinone functionalities. the ep-modified glassy carbon electrode exhibited catalytic acti...

Let C be a smooth projective irreducible curve defined over a finite field Fq of q elements and characteristic p > 3 with function field K = Fq(C). Let E/K be a non-constant elliptic curve and φ : E → C its minimal regular model. For every P ∈ C, denote by deg(P ) = [κP : Fq] its degree and qP = q deg(P . If EP = φ (P ) is an elliptic curve over κP denote by t(EP ) = qP + 1 − #EP (κP ) the trac...