نتایج جستجو برای: شاخص cpt

تعداد نتایج: 79993  

2018
Risako Kon Yuika Tsubota Moe Minami Saki Kato Yukari Matsunaga Hiroshi Kimura Yuta Murakami Tetsuya Fujikawa Ryoya Sakurai Rei Tomimoto Yoshiaki Machida Nobutomo Ikarashi Kiyoshi Sugiyama

While irinotecan (CPT-11) has a potent anti-cancer effect, it also causes serious diarrhea as an adverse reaction. In this study, we analyzed the pathogenic mechanism of CPT-11-induced delayed diarrhea by focusing on water channel aquaporin-3 (AQP3) in the colon. When rats received CPT-11, the expression level of AQP3 was reduced during severe diarrhea. It was found that the expression levels o...

Journal: :Anais da Academia Brasileira de Ciencias 2014
Giovana N M Esquissato Juliane R De Sant'anna Claudinéia C S Franco Lúcia J Rosada Paula A S R Dos Santos Marialba A A De Castro-Prado

Mitotic recombination is a process involved in carcinogenesis which can lead to genetic loss through the loss of heterozygosity. The recombinogenic potentials of two anticancer drugs topoisomerase I inhibitors, camptothecin (CPT) and irinotecan (CPT-11), were evaluated in the present study. The homozygotization assay, which assess the induction of mitotic recombination and gene homozygosis, as ...

Journal: :Circulation 1998
S E Reis V Bhoopalam K A Zell P J Counihan A J Smith S Pham S Murali

BACKGROUND Transplant-associated coronary arteriopathy is manifested in its early stages by paradoxical coronary artery constriction in response to endothelium-dependent vasodilator stimuli such as the cold pressor test (CPT) and is a major cause of death or retransplantation. Estrogen has vasoactive properties that abolish coronary artery endothelial dysfunction in native hearts. We hypothesiz...

Journal: :The journal of medical investigation : JMI 2011
Dengbing Yao Min Yao Miyoko Yamaguchi Junji Chida Hiroshi Kido

BACKGROUND In mammals, carnitine palmitoyltransferase (CPT) system is a pivotal component of energy metabolism through mitochondrial fatty acid oxidation. The majority of patients with fatal or handicapped influenza-associated encephalopathy exhibit thermolabile compound homo/heterozygous mutations of CPT II. OBJECTIVE Compound CPT II mutations, [c.647A>G (p.Q216R)], [c.1102G>A (p.V368I)], [c...

Journal: :Brain research 2006
Elif Kirmizi-Alsan Zubeyir Bayraktaroglu Hakan Gurvit Yasemin H Keskin Murat Emre Tamer Demiralp

Neuropsychological tests target specific cognitive functions; however, numerous cognitive subcomponents are involved in each test. The aim of this study was to decompose the components of two frontal executive function tests, Go/NoGo (GNG) and cued continuous performance task (CPT), by analyzing event-related potentials (ERPs) of 24 subjects both in time and time-frequency domains. In the time ...

Journal: :Cancer research 1986
P J Tofilon C M Vines F L Baker D F Deen W A Brock

The effect of cis-diamminedichloroplatinum(II) (cPt) on sister chromatid exchange (SCE) induction was determined in 13 human primary tumor cell cultures. Primary cultures were derived from surgical specimens of solid tumors composed of a variety of histologies. Three to 16 days after biopsy, depending on the growth rate, cultures were treated with graded concentrations of cPt for 1 h and the SC...

2016
Laura Astolfi Edi Simoni Filippo Valente Sara Ghiselli Stavros Hatzopoulos Milvia Chicca Alessandro Martini

Cisplatin (Cpt) is known to induce a high level of oxidative stress, resulting in an increase of reactive oxygen species damaging the inner ear and causing hearing loss at high frequencies. Studies on animal models show that antioxidants may lower Cpt-induced ototoxicity. The aim of this study is to evaluate the ototoxic effects of two different protocols of Cpt administration in a Sprague-Dawl...

2013
Jean-Paul Bonnefont Michel Colonna Claude Cepanec Jean-Paul Leroux Jean-Marie Saudubray

Reported cases of carnitine palmitoyltransferase II (CPT II) deficiency are characterized only by a muscular symptomatology in young adults although the defect is expressed in extramuscular tissues as well as in skeletal muscle. We describe here a CPT II deficiency associating hypoketotic hypoglycemia, high plasma creatine kinase level, heart beat disorders, and sudden death in a 3-mo-old boy. ...

2014
Joanna Proszek Amit Roy Ann-Katrine Jakobsen Rikke F. Frøhlich Birgitta Ruth Knudsen Magnus Stougaard

Human topoisomerase I (hTopI) is an essential cellular enzyme. The enzyme is often upregulated in cancer cells, and it is a target for chemotherapeutic drugs of the camptothecin (CPT) family. Response to CPT-based treatment is dependent on hTopI activity, and reduction in activity, and mutations in hTopI have been reported to result in CPT resistance. Therefore, hTOPI gene copy number, mRNA lev...

Journal: :Molecular pharmacology 2005
Michal Harel Janice L Hyatt Boris Brumshtein Christopher L Morton Kyoung Jin P Yoon Randy M Wadkins Israel Silman Joel L Sussman Philip M Potter

The anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino-]carbonyloxycamptothecin (CPT-11) is a highly effective camptothecin analog that has been approved for the treatment of colon cancer. It is hydrolyzed by carboxylesterases to yield 7-ethyl-10-hydroxycamptothecin (SN-38), a potent topoisomerase I poison. However, upon high-dose intravenous administration of CPT-11, a cholinergic sy...

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