Virulence genes located on pathogenicity islands play a crucial role in the pathogenesis of Salmonella enterica infections. Salmonella pathogenicity islands (SPI) contribute to host cell invasion and intracellular pathogenesis. At present, 12 SPI have been described. Although size, structure and function of these SPI, as well as the distribution in Salmonella subspecies and serovars can be mark...

Two deletion-substitution mutations of phage lambda, spi-113 and spi-274, are shown to remove about half of the rightward operator OR. Physiological studies show that spi-113 is still repressible. Thus, the 50 or so nucleotides of OR deleted in this mutant are not absolutely essential for repression. prm-116, which inactivates the promoter essential for the maintenance of lambda repressor synth...

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a major intestinal pathogen of both humans and animals. Salmonella pathogenicity island 1 (SPI-1)-encoded virulence genes are required for S. Typhimurium invasion. While oxygen (O2) limitation is an important signal for SPI-1 induction under host conditions, how the signal is received and integrated to the central SPI-1 regulatory syst...

BACKGROUND Determination of relationships between transcranial Doppler (TCD)-based spectral pulsatility index (sPI) and pulse amplitude (AMP) of intracranial pressure (ICP) in 2 groups of severe traumatic brain injury (TBI) patients (a) displaying plateau waves and (b) with unstable mean arterial pressure (MAP). METHODS We retrospectively reviewed patients with severe TBI and continuous TCD m...

Software Process Improvement (SPI) is the modification of current software process methods in many software development organizations. It is the key of the continuous process improvement. In this paper, we introduce Software Process Improvement (SPI) and Quality Function Deployment (QFD); the SPI framework based on CMMI contains two portions: 1) SPI framework for CMMI staged model based on QFD ...

This paper is aimed at ident ify ing the potent ial role of SPI CE, especially SPI CE level 3, to achieving the proposed UK public sector efficiencies. SPI CE level 3 presents the process m aturity fram ework to address the level I I I of the SPICE model. Building upon the developments of level I I , SPI CE 3 advocates establishment of a process improvement infrast ructure to facilitate good pr...