Complement is implicated in the pathogenesis of rheumatoid arthritis (RA); elevated levels of complement activation products have been measured in plasma, synovial fluid, and synovial tissues of patients. Complement polymorphisms are associated with RA in genome-wide association studies. Coding-region polymorphisms may directly impact protein activity; indeed, we have shown that complement poly...

A graph is C5-saturated if it has no five-cycle as a subgraph, but does contain a C5 after the addition of any new edge. Extending our previous result, we prove that the minimum number of edges in a C5-saturated graph on n vertices is sat(n, C5) = ⌈10(n − 1)/7⌉ − 1 for 11 ≤ n ≤ 14, or n = 16, 18, 20, and is ⌈10(n − 1)/7⌉ for all other n ≥ 5, and we also prove that the only C5-saturated graphs w...

in the present work, b-zsm-5 zeolite membranes were synthesized on porous tubular α-alumina supports by several subsequence in situ crystallization hydrothermal treatments. the tio2- bohmite and ɣ- alumina intermediate layers were applied to improve the lattice matching between zeolite layer and the support. the uniform membrane intermediate layers with low permeation resistance were prepared o...

Background and Importance: The development of C5 root palsy is a well-known potential complication of cervical spine surgeries for the correction of cervical spondylotic myelopathy. It typically occurs unilaterally but on extremely rare occasions it might occur as a bilateral anomaly. The value of intraoperative neurophysiologic monitoring in detection of iatrogenic acute versus delayed onset C...

The first recognized human kindred with hereditary deficiency of the fifth component of complement (C5) is described. The proband, a 20-year-old black female with systemic lupus erythematosus since age 11, lacked serum hemolytic complement activity, even during remission. C5 was undetectable in her serum by both immunodiffusion and hemolytic assays. Other complement components were normal durin...