Regulatory T cells (Tregs) suppress excessive immune responses and are potential therapeutic targets in autoimmune disease and organ transplantation rejection. However, their role in renal ischemia-reperfusion injury (IRI) is unclear. Levels of Tregs and expression of CXCR3 in Tregs were analyzed to investigate their function in the early phase of renal IRI. Mice were randomly divided into Sham...

BACKGROUND/AIMS Renal ischemia/reperfusion injury (IRI) is a very common clinical event and usually leads to ischemic acute renal failure (ARF). In the present study, we investigated the protective role of vitamin C in renal function and renal arterial relaxation following ischemic injury. METHODS IRI model in mice was used. Various biochemical parameters including nitric oxide (NO), reduced ...

Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury in both native kidneys and renal allografts. Disruption of the actin cytoskeleton is a key event with multiple repercussions on cell adhesion and function during IRI. However, receptors involved in regulating cytoskeletal repair following injury have not been identified. In an in vivo model of renal IRI, we used multiprob...

At Old Dominion University, we have designed and implemented a Java-based distance education system, which we term IRI-h (for Interactive Remote Instructionheterogeneous). IRI-h is designed to function on a number of heterogeneous platforms, and within heterogeneous network environments. IRI-h builds on the success of its predecessor system IRI, but attempts to avoid a number of identified pitf...

We anticipate a potential phishing strategy by obfuscation of Web links using Internationalized Resource Identifier (IRI). In the IRI scheme, the glyphs of many characters look very similar while their Unicodes are different. Hence, certain different IRIs may show high similarity. Therefore, it is quite difficult for normal Web users to distinguish them. The potential phishing attacks based on ...

Ischemia reperfusion injury (IRI) in organ transplantation remains a serious and unsolved problem. Organs that undergo significant damage during IRI, function less well immediately after reperfusion and tend to have more problems at later times when rejection can occur. Biliverdin has emerged as an agent that potently suppress IRI in rodent models. Since the use of biliverdin is being developed...

Complement is implicated in the pathogenesis of ischemia-reperfusion injury (IRI). The activation pathway(s) and effector(s) of complement in IRI may be organ specific and remain to be fully characterized. We previously developed a renal IRI model in decay-accelerating factor (DAF) and CD59 double-knockout (DAF(-/-)CD59(-/-)) mice. In this study, we used this model to dissect the pathway(s) by ...

Solar activity during 2008 2009 was extremely low among several recent solar cycles, raising an interesting question regarding the temporal and spatial distribution of the plasma parameters in ionosphere during this time period. This study analyzes the electron density (Ne) data recorded by the DEMETER satellite at the height of 670 km and compares it with the International Reference Ionosphere...

The International Reference Ionosphere (IRI) is an empirical model widely used to describe ionospheric characteristics. In the previous research, high-precision total electron content (TEC) data derived from global navigation satellite system (GNSS) were adjust index IG12 as a driving parameter in standard IRI model; thus, errors between IRI-TEC and GNSS-TEC minimized, was calibrated by modifyi...