Autoimmune response to cardiac troponin I (TnI) induces inflammation and fibrosis in the myocardium. High-mobility group box 1 (HMGB1) is a multifunctional protein that exerts proinflammatory activity by mainly binding to receptor for advanced glycation end products (RAGE). The involvement of the HMGB1-RAGE axis in the pathogenesis of inflammatory cardiomyopathy is yet not fully understood. Usi...

Cardiac hypertrophy induced by thyrotoxic stress leads to an increase in the rate of force development, velocity of shortening, tension-dependent heat generation, and myosin ATPase activity. We did studies to see whether alterations in covalent phosphorylation of myofibrillar proteins correlate with these changes. The protein preparations were isolated from control and thyrotoxic hearts of male...

Activation of the beta adrenergic receptor (betaAR) induces a tightly controlled cAMP/protein kinase A (PKA) activity to ensure an agonist dose-dependent and saturable contraction response in animal heart. We have found that stimulation of beta(1)AR by isoproterenol induces maximal contraction responses at the dose of 1 microM in cardiac myocytes; however, cAMP accumulation continues to increas...

INTRODUCTION AND OBJECTIVES Troponin I (TnI) is a useful marker of myocardial damage for the diagnosis and prognosis of acute coronary syndrome. The purpose of this study was to analyze the long-term prognostic value of the peak TnI concentration obtained within 48 h of admission to the coronary unit for unstable angina. METHODS The study included 149 consecutive patients. Serial determinatio...

Human resources are the most important assets possessed by every institution, from lowest level of institutions to highest such as state. The dynamics an uncertain and complex strategic environment have impact on defense posture TNI, which continues be demanded able balance these dynamics. In process, development TNI's experienced many obstacles, so that role human resource management (HR) was ...

OBJECTIVES Although diagnostic coronary angiography (CAG) is performed worldwide, procedure-related myocardial necrosis (PMN) following diagnostic catheter-based procedures has not been well investigated. The aim of this study was to determine clinical and procedural factors associated with PMN, using a high-sensitivity cardiac troponin I (hs-cTnI) assay, and to investigate the clinical implica...

To the Editor: The article by Feng et al1 caused a revolution in current thinking regarding the pathomechanism involved in myocardial stunning, in that it irrefutably proved that there is no causal link between troponin I (TnI) degradation and the transiently depressed contractile function after a brief ischemic episode. However, does this fact imply that there is no answer to the question of w...

The effect troponin I phosphorylation has on the Ca2+-binding properties of troponin C (TnC) in the whole troponin complex reconstituted from cardiac troponin I (TnI), troponin T, and TnC has been measured. To selectively follow Ca2+ binding at the Ca2+-specific sites of TnC, this subunit was labeled with the fluorescent probe 2-(4’-iodo-acetamidoanilino)naphthalene-6sulfonic acid before recons...

in this article the relationship between the amount of seasonal rainfall (autumn, winter and spring) and climate indices in iran have been studied. the climate indices (the southern oscillation(soi),the north atlantic oscillation(nao), arctic oscillation(ao),nino 3/4,the multivariate enso index(mei),trans_ nino index(tni) and the pacific decadal oscillation(pdo) are used as independent variable...