Chimeric-antigen-receptor (CAR) T-cell therapy for CD19-expressing B-cell malignancies is already widely adopted in clinical practice. On the other hand, development of CAR-T-cell its nascent stage. One potential targets CD26, to which we have developed and evaluated efficacy safety humanized monoclonal antibody YS110. We generated second (CD28) third (CD28/4-1BB) generation CD26-targeted CAR-T...

For a positive integer g, let Sp2g(R) denote the group of 2g× 2g symplectic matrices over a ring R. Assume g ≥ 2. For a prime number , we give a self-contained proof that any closed subgroup of Sp2g(Z ) which surjects onto Sp2g(Z/ Z) must in fact equal all of Sp2g(Z ). The result and the method of proof are both motivated by group-theoretic considerations that arise in the study of Galois repre...

For a smooth curve of genus g embedded by a line bundle of degree at least 2g + 3 we show that the ideal sheaf of the secant variety is 5-regular. This bound is sharp with respect to both the degree of the embedding and the bound on the regularity. Further, we show that the secant variety is projectively normal for the generic embedding of degree at least 2g + 3. AMS Subject Classification (200...

CONTEXT Reliable thyroglobulin (Tg) autoantibody (TgAb) detection before Tg testing for differentiated thyroid cancer (DTC) is critical when TgAb status (positive/negative) is used to authenticate sensitive second-generation immunometric assay ((2G)IMA) measurements as free from TgAb interference and when reflexing "TgAb-positive" sera to TgAb-resistant, but less sensitive, Tg methodologies (ra...

We solve the following problem: Let M be a 2g × 2g symplectic matrix of prime order with integer entries. Find a unique normal form for M , that is, a symplectic matrix whose entries are determined by its conjugacy invariants. This is equivalent to finding a unique normal form for the matrix representation of the conjugacy class of a prime order element of the mapping class group.

We apply topological methods to study eigenvalues of the Laplacian on closed hyperbolic surfaces. For any closed hyperbolic surface S of genus g , we get a geometric lower bound on 2g 2.S/ W 2g 2.S/ > 1=4C 0.S/ > 0; where 0.S/ is an explicit constant which depends only on the systole of S . Mathematics Subject Classification (2010). Primary 30F; Secondary 35P05, 35P15.