In response to neuronal injury or disease, microglia adopt distinct reactive phenotypes via the expression of different sets of genes. Spinal microglia expressing the purinergic P2X4 receptor (P2X4R) after peripheral nerve injury (PNI) are implicated in neuropathic pain. Here we show that interferon regulatory factor-5 (IRF5), which is induced in spinal microglia after PNI, is responsible for d...

OBJECTIVE To determine the prevalence, location, mechanism, and characteristics of peripheral nerve injury (PNI) in trauma patients. MATERIAL AND METHODS A retrospective study of medical records with PNI diagnosis secondary to trauma in the period of 2008-2012. The following information was collected: gender, age, occupation, anatomic location, affected nerve, mechanism of injury, degree of i...

Areas of convergence and divergence between the Narcissistic Personality Inventory (NPI; Raskin & Terry, 1988) and the Pathological Narcissism Inventory (PNI; Pincus et al., 2009) were evaluated in a sample of 586 college students. Summary scores for the NPI and PNI were not strongly correlated (r = .22) but correlations between certain subscales of these two inventories were larger (e.g., r = ...

Background: To clarify the prognostic values of serum albumin and peripheral lymphocyte count in patients with non-muscle invasive bladder cancer (NMIBC) and establish a nomogram to predict recurrence-free survival (RFS). Methods: The prognostic nutritional index (PNI) was calculated based on optimal cutoff values of 52.57. RFS was assessed using the Kaplan-Meier method and the equivalences of ...

The prognostic nutritional index (PNI) has been reported to correlate with the prognosis in patients with various malignancies. We performed a meta-analysis to determine the predictive potential of PNI in digestive system cancers. Twenty-three studies with a total of 7,384 patients suffering from digestive system carcinomas were involved in this meta-analysis. A lower PNI was significantly asso...

INTRODUCTION Peripheral nerve injuries (PNI) are among the leading causes of physical disability in the United States. The majority of injuries occur in the upper extremities, and functional recovery is often limited. Robust animal models are critical first steps for developing effective therapies to restore function after PNI. METHODS We developed an automated behavioral assay that provides ...

Pericardial patch grafts were implanted in the hearts of young sheep for periods ranging from two to 120 days. Explants seven to 21 days old revealed the formation of a "pseudoneointima" (PNI) on the blood contacting surface of the pericardium. The PNI was more heavily mineralized than the pericardium. Mineralization was most intense on the blood contacting surface of the PNI and on the chamber...

BACKGROUND Nutritional status plays an important role in the incidence of postoperative complications and the prognosis of various tumours. The prognostic value of preoperative nutritional factors in patients with pancreatic cancer is not known. METHODS This retrospective study included 268 patients who underwent resection for adenocarcinoma of the pancreas. The predictive value of preoperati...