This study is to investigate the effects of decorin (DCN) on human hepatoma HepG2 cells under oxygen-glucose deprivation (OGD) condition. HepG2 cells were cultured under OGD condition. CCK-8 assay was used to assess the cell survival, and flow cytometry was performed to detect the apoptosis. Protein expression levels were detected with Western blot analysis. Transfection was performed with lipo...

Objetivo. Determinar el efecto citotóxico e inducción de la apoptosis Deoxinivalenol (DON) sobre línea celular hepatocarcinoma humano (HepG2). Materiales y métodos. La HepG2 se expuso a concentraciones 10, 25, 50 75 µM DON liofilizado durante 48 72 horas. Posteriormente, actividad citotóxica evaluó empleando ensayo MTT (bromuro 3-(4,5-dimetil-2-tiazolil) -2, 5-difeniltetrazolio). Finalmente, an...

A series of diverse furo[2,3-d]pyrimidines (2a–2b, 4a–4d and 8a–8c) benzofuro[3,2-d]pyrimidines (12a–12c) were synthesized screened for their antitumor effects against HepG2, Bel-7402 HeLa cell lines in vitro. Representatively, 4a, with an IC50 0.70 ?M, exhibited the best activity tested HepG2 lines. Molecular docking investigation further revealed possible binding modes compound 4a receptor ty...

One undescribed and six known abietane diterpenoids were isolated as ligands for aryl hydrocarbon receptor (AhR) from leaves of Salvia officinalis, a folk medicine in the Mediterranean Sea area. The structure diterpenoid named (+)-(10R)-11,14-dioxoabieta-8,12-diene-12,20-diol was assigned by 1D/2D NMR spectroscopic HR-ESI-MS data. AhR ligand activity evaluated AhR-dependent luciferase reporter ...

objective(s):  protective effects of different extracts and essential oil from pimpinella anisum           l. seeds were examined against carbon tetrachloride (ccl4)-induced toxicity. the parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes of liver were assessed as toxicity markers. in the in...

A new compound, 1,3,7,9-tetrahydroxy-6 H-dibenzo[ b, d]pyran-6-one (1), together with 6 known compounds (2-7), was isolated from the extract of whole plants Centella asiatica. The chemical structure elucidated on basis spectroscopic and mass spectrometric analyses. All isolates were evaluated for their cytotoxicities against 4 human cancer cell lines (MCF-7, HepG2, Hela, A549). Among them, comp...