The use of bacteriophages to select novel ligands has been widely explored for cancer therapy. Their application is most warranted in cancer subtypes lacking knowledge on how to target the cancer cells in question, such as the triple negative breast cancer, eventually leading to the development of alternative nanomedicines for cancer therapeutics. Therefore, the following study aimed to select ...

Sredi onkoliticheskih virusov odnim iz naibolee izuchennyh yavlyaetsya virus ospovakciny (VV), shtamma modificirovannogo vysokoattenuirovannogo virusa Ankara (MVA), pokazavshego mnogoobeshchayushchie rezul'taty v doklinicheskih i klinicheskih ispytaniyah. SHtamm Lister VV Moskovskogo Instituta virusnyh preparatov (LIVP) issledovan men'shej stepeni, chem MVA imeet otlichnyj ot tropizm. Cel'yu ra...

Cell lines and reagents: Matrigel was from BD Biosciences. The highly metastatic lung-tropic MDA-MB231 subline 4175 was kindly provided by Dr. J. Massague [1]. MCF10A, 4T1, and 4T07 cells were kindly provided by Dr. Fred Miller (Karmanos Cancer Institute, MI). BT20 and MCF7 were purchased from ATCC. 4T1, and 4T07 cells were cultured in Dulbecco’s modified Eagle’s medium with 5% FBS, 5% newborn ...

نقش سلولهای خونی به عنوان اجزای اصلی دفاع فیزیولوژیک حشرات مهم گزارش شده است. اولین فاکتورهای سیستم گردش خون هستند که در مقابله با انواع تنشها و عوامل بیگانه مشارکت می کنند. تحقیق حاضر، چهار نوع هموسیت همولنف لارو سن چهارم خرطوم بلند دمبرگ چغندرقند شناسایی شد شامل پروهموسیتها، گرانولوسیتها، پلاسموتوسیتها انوسیتوئیدها هستند. بزرگترین از نظر اندازه بودند مجموع فراوانی گرانولوسیتها لاروهای سنین سو...

La estructura de la ftalimida es considerada un bloque construcción para el desarrollo nuevos agentes anticancerígenos. En este trabajo, se evaluó actividad antiproliferativa cuarenta y tres derivados contra las líneas celulares cancerígenas cérvix (HeLa), hígado (HepG2), mama (4T1), línea celular normal fibroblastos murinos (3T3). Por último, realizó análisis acoplamiento molecular los en siti...

Results Daily oral dose of thalidomide was able to reduce in 46% the tumor volume. Assessment of tumor vascularization revealed a significant decrease in blood vessels formation by thalidomide. The levels of two cytokines, VEGF and TNF-a were decreased in tumor samples of thalidomidetreated group compared with the control group. Accumulation of neutrophils or macrophages in the 4T1 tumor measur...

background: the adjuvanticity potential of lactobacillus casei was first suggested in an old survey. the present study was designed to investigate the efficacy of a new immunotherapy against breast cancer made by mixing an extract of heated 4t1 mammary carcinoma cell line and a heat-killed preparation of lactobacillus casei. methods: female balb/c mice (6–8 weeks old, n=40) were challenged subc...

Objective(s): The central role of molecular imaging modalities in cancer management is an undeniable fact that could help to diagnose cancer tumors in early stages. The main aim of this study is to prepare a novel targeted molecular imaging nanoprobe of CD24-PEGylated Au NPs to improve the ability of Computed tomography scanning (CT scan) outputs for both in vitro and in vivo detection of breas...