BACKGROUND Despite intensive effort, currently no effective anti-Ras therapies have successfully reached clinical application. Previous studies suggest that the histone deacetylatse (HDAC) inhibitor romidepsin, which is currently in clinical trials for the treatment of multiple malignancies, can block Ras-dependent signaling and growth transformation. These studies suggest that mutational activ...

The resource-infrastructure-environment (RIE) index was proposed as an alternative measure of progress which was then employed to: (a) compare the aggregate (single summary) index findings between Australia (mid-industrialised nation), Mexico (emerging economy), and the US (highly industrialised nation); and (b) compare the RIE index against the gross domestic product (GDP), human development i...

Based on a relation between inertial time intervals and the Rie-mannian curvature, we show that space–time uncertainty derived by Ng and van Dam implies absurd uncertainties of the Riemannian curvature .

A lithography-free method for fabricating the nanogrids and quasi-beehive nanostructures on Si substrates is developed. It combines sequential treatments of thermal annealing with reactive ion etching (RIE) on SiGe thin films grown on (100)-Si substrates. The SiGe thin films deposited by ultrahigh vacuum chemical vapor deposition form self-assembled nanoislands via the strain-induced surface ro...

Words in connected speech are often assimilated to subsequent words. Some property of that upcoming word may then be determined in advance; these advance assimilatory cues may facilitate perception of that word. A gating experiment was conducted in Dutch, studying anticipatory voice assimilation between plosives, in 24 two-word combinations. In Dutch, voicing in a word-final plosive can only be...

The authors describe a new W–Cr–HSQ trilayer nanofabrication process for high-resolution and high-diffraction-efficiency soft x-ray W zone-plate lenses. High-resolution HSQ gratings were first fabricated by electron-beam lithography and high-contrast development in a NaCl/NaOH solution. The HSQ pattern was then transferred to the Cr layer by RIE with Cl2/O2, and subsequently to the W layer by c...