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BACKGROUND Among variables obtained from cardiopulmonary exercise testing (CPXT), peak oxygen consumption (PV̇O2) and the minute ventilation vs. carbon dioxide output (V̇E vs. V̇CO2) slope were established as predictors of death of patients with heart failure (HF) at the cutoff points of 14 ml·min(-1)·kg(-1)and 34, respectively. However, a recent update of guideline-directed medical treatment (GDM...

Throughout the history of East Asian medicine, different kinds of acupuncture treatment experiences have been accumulated in classical medical texts. Reexamining knowledge from classical medical texts is expected to provide meaningful information that could be utilized in current medical practices. In this study, we used data mining methods to analyze the association between acupoints and patte...

Greenhouse gas emissions can trigger irreversible regime shifts in the climate system, known as tipping points. Multiple tipping points a ect each other’s probability of occurrence, potentially causing a ‘domino e ect’. We analyse climate policy in the presence of a potential domino e ect. We incorporate three di erent tipping points occurring at unknown thresholds into an integrated climate–ec...

BACKGROUND We set out to identify the level of previous exposure to influenza A (H1N1) in unvaccinated healthcare workers (HCWs) at the peak of the pandemic outbreak in the UK, with control samples collected prior to the outbreak. METHODS Cross-sectional study (seroprevalence assessed before and at pandemic peak, with questionnaire data collected at peak of outbreak) in HCWs in Scotland. RE...

BACKGROUND The aesthetically appealing eyebrow shape has been defined by its arch, located near the junction between the medial two-thirds and lateral one-third. The position of this arch has been historically described by arbitrary anatomical landmarks that have no logical structural relationship. Moreover, selection of endoscopic brow lift incision sites that define vector of pull and fixatio...

BACKGROUND The relationship between troponin level and outcomes among patients with non-ST-segment elevation ACS is established, but the relationship of troponin level with long-term outcomes among medically managed non-ST-segment elevation ACS patients receiving contemporary antiplatelet therapy is inadequately defined. METHODS AND RESULTS In 6763 medically managed non-ST-segment elevation A...