The oligosaccharide donor for protein N-glycosylation, Glc(3)Man(9)GlcNAc(2)-PP-dolichol, is synthesized via a multistep pathway that starts on the cytoplasmic face of the endoplasmic reticulum (ER) and ends in the lumen where the glycosylation reaction occurs. This necessitates transbilayer translocation or flipping of the lipid intermediate Man(5)GlcNAc(2)-PP-dolichol (M5-DLO) across the ER m...

3-n-Butylphthalide (NBP) is a cardiovascular drug currently used for the treatment of cerebral ischemia. The present study aims to investigate the metabolism, pharmacokinetics, and excretion of NBP in humans and identify the enzymes responsible for the formation of major metabolites. NBP underwent extensive metabolism after an oral administration of 200 mg NBP and 23metabolites were identified ...

We derive an explicit form of the quadratic-in-fermions Dirac action on the M5 brane for an arbitrary on-shell background of 11D supergravity with non-vanishing fluxes and in presence of a chiral 2-form on M5. This action may be used to generalize the conditions for which the non-perturbative superpotential can be generated in M/string theory. We also derive the Dirac action with bulk fluxes on...

Ruth Aylett, Centre for Virtual Environments, University of Salford, Salford, Greater Manchester, M5 4WT, UK. [email protected]. Gary Petley, Centre for Virtual Environments, University of Salford, Salford, Greater Manchester, M5 4WT, UK. [email protected]. Paul Chung, Chemical Engineering Department, Loughborough University, Loughborough, Leicestershire, LE11 3TU, ...

We derive the dynamics of M-brane intersections from the worldvolume action of one brane in the background supergravity solution of another one. In this way we obtain an effective action for the self-dual string boundary of an M2-brane in an M5-brane, and show that the dynamics of the 3-brane intersection of two M5-branes is described by a Dirac-Born-Infeld action. Permanent adress University o...