Mycobacterium tuberculosis, the main cause of tuberculosis (TB), has still remained a global health crisis especially in developing countries. Tuberculosis treatment is a laborious and lengthy process with high risk of non compliance, cytotoxicity adverse events and drug resistance in patient. Recently, there has been an alarming rise of drug resistant in TB. In this regard, it is an unmet need...

Background: Multiple sclerosis (MS) is an autoimmune disease that causes chronic inflammation of the central nervous system. MicroRNAs (miRNAs) are small non-coding RNAs 19–24 nucleotides long, which are differentially expressed in different tissues. The role of miRNAs in MS remains unclear. We assessed miR-10a transcript levels in MS patients during recurrence and two months after relapse. Ma...

Literacy underpins constitutions, civil rights and liberties. But E-mail is replacing the letter; the digital certificate, the written signature. Printing allows the recording and dissemination of observations, thoughts and ideas. But the Internet is competing with the printed page; the searchable database with the index of contents. If you are reading this article online, you may have retrieve...

Mycobacterium tuberculosis, the main cause of tuberculosis (TB), has still remained a global health crisis especially in developing countries. Tuberculosis treatment is a laborious and lengthy process with high risk of non compliance, cytotoxicity adverse events and drug resistance in patient. Recently, there has been an alarming rise of drug resistant in TB. In this regard, it is an unmet need...

هدف: با توجه به کاستی‌های موجود، نظام سیاست‌گذاری سازمانی فرایندی سیستماتیک، هدفمند و منظم برای تولید داده‌های حاصل از عملکرد، پردازش آن‌ها اطلاعات تبدیل آن دانش سیاستی نیاز دارد تا نسبت کم کیف تحقق اهداف سیاست‌ها، آثار پیامدهای موفقیت یا ناکامی‌شان آگاهی داشته تصمیم‌گیری بهره گیرد. ازاین‌رو مسئله اصلی که محقق تلاش رفع می‌پردازد تبیین این موضوع است سیاست‌ها راهبردهای کلان چه پیامدها آثاری در پی...

Background: Antioxidants are developed to assist the immune system and overcome oxidative stress, the aggression of cellular constituents due to imbalance between reactive oxygen species and the inner antioxidant system. The main objective of this study was to search for new and potent antioxidants to protect humans against diseases associated with oxidative stress. Methods: In this study, thr...

Accumulating evidence indicates that toll-like receptor 4 (TLR4) plays a critical role in promoting adaptive immune responses and are definitively involved in the expansion and maintenance of the neuropathic pain. However, the application of docking in virtual-screening in silico methods to drug discovery has some challenge but it allows us to make the directed and meaningful design of drugs fo...