The sulfur oxygenase reductase (Sor) catalyzes the oxygen dependent disproportionation of elemental sulfur, producing sulfite, thiosulfate and sulfide. Being considered an "archaeal like" enzyme, it is also encoded in the genomes of some acidophilic leaching bacteria such as Acidithiobacillus caldus, Acidithiobacillus thiooxidans, Acidithiobacillus ferrivorans and Sulfobacillus thermosulfidooxi...

Although inhibition of cyclooxygenase-2 (COX-2) or the vascular endothelial growth factor receptor (VEGFR) has been shown to be a promising antitumor strategy in non-small cell lung cancer (NSCLC), the therapeutic efficacy is limited due to inherent tumor resistance. In the present study, we selected sorafenib (SOR), a VEGFR inhibitor, in combination with celecoxib (CXB), a COX-2 inhibitor, for...

Two mutant strains of Desulfovibrio vulgaris Hildenborough lacking either the sod gene for periplasmic superoxide dismutase or the rbr gene for rubrerythrin, a cytoplasmic hydrogen peroxide (H(2)O(2)) reductase, were constructed. Their resistance to oxidative stress was compared to that of the wild-type and of a sor mutant lacking the gene for the cytoplasmic superoxide reductase. The sor mutan...

■ EVIDENCE-BASED ANSWER Erythromycin, clarithromycin, and azithromycin are equally effective in treating pneumonia caused by Mycoplasma pneumoniae or Chlamydophila (formerly Chlamydia) pneumoniae (strength of recommendation [SOR]: B, small head-to-head trials). Macrolide choice can be based on other considerations—cost, side effects, and effectiveness against other suspected pathogens (SOR: C, ...

This paper describes a method for the numerical solution of linear systems of equations. The method is a two-parameter generalization of the Successive Overrelaxation (SOR) method such that when the two parameters involved are equal it coincides with the SOR method. Finally, a numerical example is given to show the superiority of the new method.

We consider the application of semi-iterative methods (SIM) to the standard (SOR) method with complex relaxation parameter ω, under the following two assumptions: (1) the associated Jacobi matrix J is consistently ordered and weakly cyclic of index 2, and (2) the spectrum σ(J ) of J belongs to a compact subset of the complex plane C, which is symmetric with respect to the origin. By using resul...

■ EVIDENCE-BASED ANSWER There is no compelling evidence that outpatient diagnostic workup of patients with transient ischemic attack (TIA) is less safe than inpatient workup, or that hospitalization prevents stroke or improves stroke outcomes after TIA (strength of recommendation [SOR]: C, based on case series studies). Because the risk of stroke is substantial in the week following a TIA (SOR:...

and CN2 have been shown to bind to the catalytic iron site of SOR, and cyanide acts as an inhibitor. To understand how these exogenous ligands alter the physical and reactivity properties of the SOR iron site, acetate-, azide-, and cyanide-ligated synthetic models of SOR have been prepared. The x-ray crystal structures of azideligated [Fe(SN4(tren))(N3)] (3), dimeric cyanide-bridged ([Fe(SN4(tr...

Compared with planned repeat low-transverse cesarean section, vaginal birth after cesarean section (VBAC) is not associated with increased risk of maternal or neonatal mortality (strength of recommendation [SOR]: B). Morbidity is slightly increased, as evidenced by higher uterine rupture rates and some neonatal outcome measures (SOR: B).

After surgical anterior cruciate ligament (ACL) reconstruction, knee bracing does not significantly protect against injury during recovery or afterwards (strength of recommendation [SOR]: C, based on expert opinion). In addition, the use of a knee brace following ACL reconstruction does not improve stability or hasten rehabilitation, either immediately or for up to 2 years (SOR: A, based on ran...