MDMA (3,4-methylenedioxymethamphetamine; Ecstasy) is a popular recreational drug that produces long-lasting serotonin (5-HT) neurotoxicity consisting of reductions in markers for 5-HT axons. 5-HT innervates cortical and subcortical brain regions mediating motor function, predicting that MDMA users will have altered motor system neurophysiology. We used functional magnetic resonance imaging (fMR...

A new pathogen, Pseudomonas syringae pv. averrhoi (Pav), which causes bacterial spot disease on carambola was identified in Taiwan in 1997. Many strains of this pathovar have been isolated from different locations and several varieties of hosts. Some of these strains, such as HL1, are nonmotile and elicit a strong hypersensitive response (HR) in nonhost tobacco leaves, while other strains, such...

Polymorphisms in the TAS2R38 gene provide insight to phenotypes long associated 6-n-propylthiouracil (PROP) and phenylthiocarbamide bitterness. We tested relationships between TAS2R38 genotype, taste phenotype, and fungiform papillae (FP) number in 139 females and 59 males (age range 21-60 years), primarily of European ancestry. DNA was analyzed for 3 polymorphic sites, identifying common (alan...

There has been much recent interest in application of the pool-adjacent-violators (PAV) algorithm for the purpose of calibrating the probabilistic outputs of automatic pattern recognition and machine learning algorithms. Special cost functions, known as proper scoring rules form natural objective functions to judge the goodness of such calibration. We show that for binary pattern classifiers, t...

The main methodological drawback to use physiological measures as indicators of arousal is, the large interindividual variability of autonomic responses hindering the direct comparability, between individuals. The present methodology has been tested in two cohorts (n1=910, n2=845) of, pilot applicants during a selection procedure. Physiological data were obtained during two mentally, demanding ...

Discrete log based identiication and signature schemes are well-suited to identity proof and signature generation, but not suitable for veriication, by smart cards, due to their highly asymmetric computational load between the prover/signer and the veriier. In this paper, we present very eecient and practical protocols for fast veriication in these schemes, where the veriier with limited comput...

The research objectives were to identify the secondary metabolite components, total phenolic content and determine antioxidant activity of ethanol extract red betel leaf (Piper crocatum Ruiz & Pav.). extraction process was carried out by materation using as a solvent. Determination colorimetrically with Folin-Ciocalteu reagent measured at maximum wavelength 765 nm. DPPH method spectrophotom...

Objetivos: identificar as diferentes formas de utilização da clorexidina para higiene bucal pacientes em ambiente UTI e qual proporciona maior índice redução PAV. Métodos: foi realizada uma Revisão Sistemática, que teve como estratégia PICO, internados na UTI, submetidos à com clorexidina, avaliando o resultado Resultados: a solução 0,12% é mais utilizada gerou Metanálise 5 estudos mostraram nã...