نتایج جستجو برای: روش mpn

تعداد نتایج: 371287  

Journal: :The Kurume medical journal 2014
Yuka Takata Ritsuko Seki Taisuke Kanajii Masayuki Nohara Satoko Koteda Kuniki Kawaguchi Kei Nomura Takayuki Nakamura Satoshi Morishige Eijirou Oku Koichi Osaki Emichitoshi Hashiguchi Fumihiko Mouri Koji Yoshimoto Koji Nagafuji Takashi Okamura

Thrombotic complications are a major cause of death in patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs), which are closely associated with the JAK2 V617F activating mutation. However, whether the presence of the JAK2 V617F mutation affects thrombotic risk is currently unknown, although some reports have suggested a variable association with thrombosis. Therefor...

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Journal: :Blood 2011
Angela G Fleischman Karl J Aichberger Samuel B Luty Thomas G Bumm Curtis L Petersen Shirin Doratotaj Kavin B Vasudevan Dorian H LaTocha Fei Yang Richard D Press Marc M Loriaux Heike L Pahl Richard T Silver Anupriya Agarwal Thomas O'Hare Brian J Druker Grover C Bagby Michael W Deininger

Proinflammatory cytokines such as TNFα are elevated in patients with myeloproliferative neoplasms (MPN), but their contribution to disease pathogenesis is unknown. Here we reveal a central role for TNFα in promoting clonal dominance of JAK2(V617F) expressing cells in MPN. We show that JAK2(V617F) kinase regulates TNFα expression in cell lines and primary MPN cells and TNFα expression is correla...

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Journal: :Journal of Neurology, Neurosurgery & Psychiatry 1996

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2012
M. Sokolova N. Tsvetaeva G. Sukhanova S. Vasiliev A. Misurin M. Sanatko M. Nareiko V. Rudakova E. Semenova N. Khoroshko

Dear Editor, Valla and his team pioneered the thorough search for latent myeloproliferative neoplasms (MPN) in patients with splanchnic thrombosis. They noticed that “primary myeloproliferative disorder, often without peripheral blood changes, is a major cause of hepatic vein thrombosis”. Valla provided precious guidelines for anticoagulant therapy suggesting to start anticoagulation as early a...

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2014
Pontus Lundberg Hitoshi Takizawa Lucia Kubovcakova Guoji Guo Hui Hao-Shen Stephan Dirnhofer Stuart H. Orkin Markus G. Manz Radek C. Skoda

The majority of patients with myeloproliferative neoplasms (MPNs) carry a somatic JAK2-V617F mutation. Because additional mutations can precede JAK2-V617F, it is questioned whether JAK2-V617F alone can initiate MPN. Several mouse models have demonstrated that JAK2-V617F can cause MPN; however, in all these models disease was polyclonal. Conversely, cancer initiates at the single cell level, but...

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2013
Sung-Nam Lim Je-Hwan Lee Jung-Hee Lee Dae-Young Kim Sung Doo Kim Young-A Kang Young-Shin Lee Kyoo-Hyung Lee

BACKGROUND In adults, the 2 main types of myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are chronic myelomonocytic leukemia (CMML) and atypical chronic myeloid leukemia (aCML). Both are associated with a poor prognosis. Allogeneic hematopoietic cell transplantation (HCT) is the only known curative treatment modality for these diseases, but data on outcomes following such treatment are ...

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2012
Marcel Sluijter Silvia Estevão Theo Hoogenboezem Nico G. Hartwig Annemarie M. C. van Rossum Cornelis Vink

The DNA recombination and repair machineries of Mycoplasma genitalium and Mycoplasma pneumoniae differ considerably from those of gram-positive and gram-negative bacteria. Most notably, M. pneumoniae is unable to express a functional RecU Holliday junction (HJ) resolvase. In addition, the RuvB homologues from both M. pneumoniae and M. genitalium only exhibit DNA helicase activity but not HJ bra...

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Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
D E Wood W Stein M P Nusbaum

Specificity in the actions of different modulatory neurons is often attributed to their having distinct cotransmitter complements. We are assessing the validity of this hypothesis with the stomatogastric nervous system of the crab Cancer borealis. In this nervous system, the stomatogastric ganglion (STG) contains a multifunctional network that generates the gastric mill and pyloric rhythms. Two...

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2015
Arun Rajasekaran Thuy-Trang Ngo Maen Abdelrahim William Glass Amber Podoll Srdan Verstovsek Ala Abudayyeh

BACKGROUND Primary myelofibrosis (PMF) is a type of myeloproliferative neoplasm (MPN) characterized by the predominant proliferation of megakaryocytes and granulocytes in the bone marrow, leading to the deposition of fibrous tissue, and by a propensity toward extramedullary hematopoiesis. Renal involvement in PMF is rare, but kidney tissue samples from these patients reveal MPN-related glomerul...

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2011
S. Kashyap

Nine different receptacles were tested with the MPN method to determine which receptacle was most reliable and economical for MPN counts. Results showed that 96 well PCR plate were the best vessels for this type of analysis and facilitated the isolation of viable Methylotrophs.

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