Senescent human diploid cells (HDC) were fused to replicative transformed cells of different types, and DNA synthesis was monitored in the resulting heterodikaryons. Human cells transformed by simian virus 40 or adenovirus serotype 5 were able to induce DNA synthesis in senescent HDC nuclei in heterodikaryons. In contrast, carcinogen-transformed cells were not able to induce DNA synthesis in se...

To evaluate the role of high-dose chemotherapy (HDC) followed by autologous bone marrow transplantation (ABMT) in children with poor-prognosis Burkitt's lymphoma, the European Lymphoma BMT registry was critically reviewed. Between February 1979 and July 1991, a selected group of 89 children (78 boys and 11 girls) were considered as ABMT candidates in 12 European cancer centers for the following...

Laryngeally echolocating bats avoid self-deafening (forward masking) by separating pulse and echo either in time using low duty cycle (LDC) echolocation, or in frequency using high duty cycle (HDC) echolocation. HDC echolocators are specialized to detect fluttering targets in cluttered environments. HDC echolocation is found only in the families Rhinolophidae and Hipposideridae in the Old World...

BACKGROUND High-dose chemotherapy (HDC) using sequential cycles of carboplatin/etoposide is curative for relapsed germ-cell tumors (GCT). However, outcomes of high-risk patients in advanced relapse remain poor. We previously developed a new HDC regimen combining infusional gemcitabine with docetaxel/melphalan/carboplatin (GemDMC), with preliminary high activity in refractory GCT. Given the high...

Hemodialysis catheters (HDC) are the commonly used vascular access for hemodialysis. Functioning is essential adequate dialysis. Dialysis catheter insertion under ultrasound guidance now standard practice and has reduced incidence of mechanical complications during insertion. However, such as tip misplacement puncture mediastinum cannot be prevented by ultrasound-guided procedures alone. We rep...

Introduction The concept of bone anchors constructed of High Density Collagen (HDC) was introduced at this meeting last year. The healing of tendon to bone in an animal model during the critical first six months was found to be equal to that produced with a standard metallic anchor. Collagen is being investigated as a material for making anchors to avoid the drawbacks of the materials in the cu...

Histamine and prostaglandins (PGs) play a variety of physiological roles as autacoids, which function in the vicinity of their sources and maintain local homeostasis in the body. They stimulate target cells by acting on their specific receptors, which are coupled to trimeric G proteins. For the precise understanding of the physiological roles of histamine and PGs, it is necessary to clarify the...

This paper describes a hierarchical distributed control (HDC) model for coordinating cooperative problem-solving among intelligent systems. The model was implemented using SOCIAL, an innovative object-oriented tool for integrating heterogeneous, distributed software systems. SOCIAL embeds applications in “wrapper” objects called Agents, which supply predefined capabilities for distributed commu...