METHODS: Study subjects were at least 18 years of age and had moderate (GLS=2) to severe (GLS=3) glabellar lines at maximum frown, on the 4-point photonumeric Glabellar Line Scale (GLS, 0=no lines, 1=mild, 2=moderate, 3=severe). Subjects were randomly assigned in a 3:1 ratio to receive a single treatment (0.1 mL injected into each of 5 target sites in the glabellar region) of either DWP450 (tot...

The Traveling Salesman Problem (TSP) is one of the most famous problems in combinatorial optimization. In this paper, we are going to examine how the techniques of Guided Local Search (GLS) and Fast Local Search (FLS) can be applied to the problem. Guided Local Search sits on top of local search heuristics and has as a main aim to guide these procedures in exploring efficiently and effectively ...

Recently, path flow estimators (PFE) have been used for the estimation of origin–destination (O–D) matrices. This paper develops a formulation that incorporates a decoupled path flow estimator in a generalized least squares (GLS) framework. The approach seeks to solve a GLS problem that minimizes the sum of errors in traffic counts and O–D matrices based on an equilibrium assignment mapping der...

Mushroom β-glucans are potent immunological stimulators in medicine, but their productivities are very low. In this study, we successfully improved its production by promoter engineering in Pleurotus ostreatus. The promoter for β-1,3-glucan synthase gene (GLS) was replaced by the promoter of glyceraldehyde-3-phosphate dehydrogenase gene of Aspergillus nidulans. The homologous recombination frag...

Gray leaf spot (GLS) is a major maize disease in Brazil that significantly affects grain production. We used Bayesian inference to investigate the nature and magnitude of gene effects related to GLS resistance by evaluation of contrasting lines and segregating populations. The experiment was arranged in a randomized block design with three replications and the mean values were analyzed us...

BACKGROUND We have developed new universal strain software (USS) that can be used to perform speckle tracking of any Digital Imaging and Communications in Medicine (DICOM) image, regardless of the ultrasound system used to obtain it. METHODS Fifty patients prospectively underwent echocardiography immediately prior to cardiac catheterization. Biplane peak global longitudinal strain (GLS), peak...

AIMS The aim of the present study was to evaluate whether subclinical left ventricular (LV) systolic dysfunction is independently related to subclinical coronary atherosclerosis in type 2 diabetic patients and if it could provide incremental information over baseline characteristics to identify high-risk patients. METHODS AND RESULTS A total of 234 asymptomatic, type 2 diabetic patients witho...

Speckle-tracking analysis is a new available tool in order to assess left ventricular function in cardiology. Its novelty relies on the technological ability to track natural acoustic markers (known as speckle) within the myocardium during the cardiac cycle. This technology allows the evaluation of myocardium strain during systole and diastole. To date, global longitudinal strain (GLS) has been...

BACKGROUND In chronic heart failure (CHF), the finding of elevated levels of the N-terminal fragment of the pro B-type natriuretic peptide (NT-proBNP) is a marker of pathological increase in myocardial ventricular wall stress and detrimental rise in ventricular filling pressures. However, the ensemble of data concerning the relationship between longitudinal deformation indices and NT-proBNP is ...