BACKGROUND Drug hypersensitivity syndrome (DHS) can present in several clinical forms ranging from simple maculopapular skin rash to severe bullous reactions and multi-system dysfunction. Genetic analysis of DHS patients has revealed a striking association between carbamazepine (CBZ)-induced severe bullous reactions, such as Steven-Johnson Syndrome, and toxic epidermal necrolysis in individuals...

BACKGROUND The cystic fibrosis transmembrane conductance regulator gene (CFTR) shows a complex pattern of expression. The regulatory elements conferring tissue-specific and temporal regulation are thought to lie mainly outside the promoter region. Previously, we identified DNase I hypersensitive sites (DHS) that may contain regulatory elements associated with the CFTR gene at -79.5 and at -20.5...

Performance efficiency in a Downflow Hanging Sponge (DHS) bioreactor is associated with the amount of time that a wastewater remains in the bioreactor. The bioreactor is considered as a plug flow reactor and its hydraulic residence time (HRT) depends on the void volume of packing material and the flow rate. In this study, hydraulic behavior of DHS bioreactor was investigated by using tracer met...

Previous studies of the physiology of an aromatic-deficient mutant strain of Neurospora crassa, Y7655a (1, 2), have led to the following conclusions: (a) The biosynthesis of the aromatic rings of phenylalanine, tyrosine, tryptophan and p-aminobenzoic acid proceeds in Neurospora as it does in Escherichia coli (3) via 5-dehydroshikimic acid and shikimic acid. (b) Protocatechuic acid, the major co...

Background Infertility is a neglected service component in the public health-care system in India. Objectives This study aims to assess the availability and practices on prevention and management services for infertility in the district health system. Methodology A cross-sectional survey of selected health facilities and the staff from 12 district hospitals (DHs), 24 community health center...

Regulation of expression of the CFTR gene is poorly understood. Elements within the basal promoter of the gene do not fully explain CFTR expression patterns, suggesting that cis-regulatory elements are located elsewhere, either within the locus or in adjacent chromatin. We previously mapped DNase I hypersensitive sites (DHS) in 400 kb spanning the CFTR locus including a cluster of sites close t...

OBJECTIVE The objective of this paper is to measure the volume occupied by the most widely used internal fixation devices for treating femoral neck fractures, using the first 30, 40 and 50 mm of insertion of each screw as an approximation. The study aimed to observe which of these implants caused least bone aggression. METHODS Five types of cannulated screws and four types of dynamic hip scre...

In this retrospective study, we examine the impact that Background employing a permanent derotation screw (DRS) has on the rate of revision for 2-hole dynamic hip screws (DHS, a.k.a. sliding hip screws), used for internal fixation of intracapsular neck of femur (NOF) fractures. To the best of our knowledge, we are the first to examine the impact of using a derotation screw on DHS revision rate....

PURPOSE OF THE STUDY The objective of this study was to establish relative fixation strengths of proximal femoral nail (PFN), dynamic hip screw (DHS), monolateral external fixator (EF), and cannulated screw (CS) in basicervical hip fracture model. MATERIAL AND METHODS The study involved four groups of implanted composite proximal femoral synthetic bones of eight specimens per group; nailing wit...

In order to evaluate twelve doubled haploids (DHs) of Theobroma cacao L. used as parents, a trial was set up in Côte d'Ivoire. Several traits were observed, such as yield, vigour, yield/vigour ratios, resistance to the black pod disease caused by Phytophthora, percentage of flat beans and mean weight of 100 cocoa beans. Out of the three progenies derived from crosses between two DHs, two showed...