نتایج جستجو برای: روش blm

تعداد نتایج: 371113  

Journal: :Journal of Current Chinese Affairs 2023

Why and how has China covered the Black Lives Matter (BLM), a movement with emerging themes closely related to its domestic issues? To what extent does Chinese media build unified discourse on sensitive that underpin BLM? These are important questions given China's complicated history ethnicity, race, protests. This article argues uses BLM as multi-faceted propaganda tool foster cohesion at ide...

2010
K. VACEK

The potential of lecithin BLM with chlorophyll a and with and without carotene has been measured. The BLM containing both chlorophyll a and carotene have shown the highest value of the photopotential. Stronger fatigue effect during light puis excitation has been found on BLM with pigments than with isolated chlorophyll a-protein complex extracted from blue green alga.

Journal: :Journal of the American Chemical Society 2012
Sheng-Xiong Huang Zhiyang Feng Liyan Wang Ute Galm Evelyn Wendt-Pienkowski Dong Yang Meifeng Tao Jane M Coughlin Yanwen Duan Ben Shen

The bleomycins (BLMs) are used clinically in combination with a number of other agents for the treatment of several types of tumors, and the BLM, etoposide, and cisplatin treatment regimen cures 90-95% of metastatic testicular cancer patients. BLM-induced pneumonitis is the most feared, dose-limiting side effect of BLM in chemotherapy, which can progress into lung fibrosis and affect up to 46% ...

2013
Siwei Tang Huimin Bao Yang Zhang Jun Yao Pengyuan Yang Xian Chen

BACKGROUND Lack of understanding of the response of hepatocellular carcinoma (HCC) to anticancer drugs causes the high mortality of HCC patients. Bleomycin (BLM) that induces DNA damage is clinically used for cancer therapy, while the mechanism underlying BLM-induced DNA damage response (DDR) in HCC cells remains ambiguous. Given that 14-3-3 proteins are broadly involved in regulation of divers...

Journal: :The Journal of biological chemistry 2011
Hua Fung Bruce Demple

Ionizing radiation (IR) and bleomycin (BLM) are used to treat various types of cancers. Both agents generate cytotoxic double strand breaks (DSB) and abasic (apurinic/apyrimidinic (AP)) sites in DNA. The human AP endonuclease Ape1 acts on abasic or 3'-blocking DNA lesions such as those generated by IR or BLM. We examined the effect of siRNA-mediated Ape1 suppression on DNA repair and cellular r...

Journal: :Journal of natural products 2002
Ben Shen Liangcheng Du Cesar Sanchez Daniel J Edwards Mei Chen Jeffrey M Murrell

Bleomycin (BLM) biosynthesis has been studied as a model for hybrid peptide-polyketide natural product biosynthesis. Cloning, sequencing, and biochemical characterization of the blm biosynthetic gene cluster from Streptomyces verticillus ATCC15003 revealed that (1) the BLM hybrid peptide-polyketide aglycon is assembled by the BLM megasynthetase that consists of both nonribosomal peptide synthet...

Journal: :jundishapur journal of natural pharmaceutical products 0
ali asghar hemmeti department of pharmacology and toxicology, school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; physiology research center, ahvaz jundishapur university of medical sciences, ahvaz, ir iran mohammad rahim zerafatfard department of pharmacology and toxicology, school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, ir iran mehdi goudarzi department of pharmacology and toxicology, school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, ir iran mohammad javad khodayar department of pharmacology and toxicology, school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; toxicology research center, ahvaz jundishapur university of medical sciences, ahvaz, ir iran; department of pharmacology and toxicology, school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, ir iran. tel: +98-6133738378 anahita rezaie department of pathobiology, faculty of veterinary medicine, shahid chamran university of ahvaz, ahvaz, iran mohammad reza rashidi nooshabadi department of pharmacology and toxicology, school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, ir iran

conclusions atorvastatin may play a protective role in pulmonary fibrosis, with its effects mediated via the station’s antioxidant and anti-inflammatory properties. atorvastatin may be a potential agent for the treatment of lung injury and fibrosis. background pulmonary fibrosis is an idiopathic and chronic inflammatory interstitial lung disease, with a negligible response to available medical t...

Journal: :Cancer research 1990
A E Huot R M Gundel M P Hacker

Bleomycin (BLM) has been successfully used to treat a number of human neoplasms. The main toxicity associated with BLM therapy is an acute pulmonary inflammation that can culminate in diffuse chronic fibrosis. The effect of BLM-induced pulmonary inflammation on the cytostatic activity of alveolar macrophages (AM) was investigated using AM obtained from rats that had been previously treated with...

Journal: :The Tohoku journal of experimental medicine 2008
Masato Tashiro Koichi Izumikawa Daisuke Yoshioka Shigeki Nakamura Shintaro Kurihara Noriho Sakamoto Masafumi Seki Hiroshi Kakeya Yoshihiro Yamamoto Katunori Yanagihara Hiroshi Mukae Tomayoshi Hayashi Kiyoyasu Fukushima Takayoshi Tashiro Shigeru Kohno

Bleomycin (BLM) is a chemotherapeutic agent used for the treatment of several types of malignancy, including germ cell tumors, lymphoma, and certain types of squamous-cell carcinoma. The common adverse effect of BLM is interstitial pneumonitis, followed by pulmonary fibrosis. BLM-induced pneumonitis occurs in up to 46% of patients treated with BLM-containing chemotherapy and lung toxicity usual...

Journal: :Chemical research in toxicology 1988
J B Shipley S M Hecht

Sir: The bleomycins (BLM’s) are a family of structurally complex glycoprotein antibiotics possessing significant anticancer activity ( I ) . They have been demonstrated to effect DNA strand scission in a reaction that is both metal ion and oxygen dependent (2); this transformation is believed to form the basis for the therapeutic efficacy of the bleomycins. A number of studies have demonstrated...

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