Necdin, a pleiotropic protein that promotes differentiation and survival of mammalian neurons, is a member of MAGE (melanoma antigen) family proteins that share a highly conserved MAGE homology domain. Several MAGE proteins interact with ubiquitin E3 ligases and modulate their activities. However, it remains unknown whether MAGE family proteins interact with SUMO (small ubiquitin-like modifier)...

The use of Privacy Impact Assessments (PIAs) has become common practice in a variety of jurisdictions since the mid 1990s. They play a crucial role in achieving privacy protection for data subjects and in supporting risk management for organisations. Many guidance documents have been published to help support organisations in performing PIAs and in achieving their intended benefits. However, th...

Protein modifications with small ubiquitin–like modifier (SUMO) have been found to play a key role in regulating the formation of atherosclerosis. SUMO proteins covalently modify certain residues of specific target substrates and change the function of these substrates. It has been well established that the protein inhibitor of activated STAT (PIAS) family of proteins has not only SUMO E3 ligas...

Corticosteroid actions in the brain are exerted via the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR). These receptors share several structural and functional similarities but their activation in the brain triggers distinct biological actions, for instance on neuronal survival or the regulation of the hypothalamo-pituitary-adrenal axis. Like other hormone-activated receptors,...