Background & Objective: In traditional medicine, leaves of white mulberry (Morus alba L.) are used as antidiabetic agents. Considering the presence of flavonoids, this plant exhibits insulin mimetic activities. Nesfatin-1 is described as an anorexigenic regulatory peptide, which can influence glucose metabolism via insulin sensitivity enhancement. This study examined the effects of both mulberr...

The maximum likelihood estimator (MLE) for the proportional hazards model with current status data is studied. It is shown that the MLE for the regression parameter is asymptotically normal with vn-convergence rate and achieves the information bound, even though the MLE for the baseline cumulative hazard function only converges at nI/3 rate. Estimation of the asymptotic variance matrix for the ...

The mle(napts) mutation causes temperature-dependent blockade of action potentials resulting from decreased abundance of para-encoded Na+ channels. Although maleless (mle) encodes a double-stranded RNA (dsRNA) helicase, exactly how mle(napts) affects para expression remained uncertain. Here, we show that para transcripts undergo adenosine-to-inosine (A-to-I) RNA editing via a mechanism that app...

This article considers the nonparametric maximum likelihood estimator (MLE) for the joint distribution function of an interval censored survival time and a continuous mark variable. We derive a new explicit formula for the MLE that has both computational and theoretical advantages. Using this formula and the mark specific cumulative hazard function of Huang & Louis (1998), we derive the almost ...

BACKGROUND In rats, esophagogastroduodenal anastomosis (EGDA) without concomitant chemical carcinogen treatment leads to gastroesophageal reflux disease, multilayered epithelium (MLE, a presumed precursor in intestinal metaplasia), columnar-lined esophagus, dysplasia, and esophageal adenocarcinoma. Previously we have shown that columnar-lined esophagus in EGDA rats resembled human Barrett's eso...

Drosophila maleless (mle) is required for X chromosome dosage compensation and is essential for male viability. Maleless protein (MLE) is highly homologous to human RNA helicase A and the bovine counterpart of RNA helicase A, nuclear helicase II. In this report, we demonstrate that MLE protein, overexpressed and purified from Sf9 cells infected with recombinant baculovirus, possesses RNA/DNA he...

We study a class of quadratic stochastic programs where the distribution of random variables has unknown parameters. A traditional approach is to estimate the parameters using a maximum likelihood estimator (MLE) and to use this as input in the optimization problem. For the unconstrained case, we show that an estimator that shrinks the MLE towards an arbitrary vector yields a uniformly better r...