Rhabdomyolysis may result from various factors, namely trauma, exercise, medications, infections, endocrine disorders, congenital myopathies, and metabolic diseases. Among the latter, mitochondrial fatty acid b-oxidation (FAO) defects frequently cause recurrent rhabdomyolysis. FAO disorders are recessively inherited and have a combined incidence of 1:9,300, estimated after implementation of new...

Abnormalities of fatty acid metabolism are recognized to play a significant role in human disease, but the mechanisms remain poorly understood. Long-chain acyl-CoA dehydrogenase (LCAD) catalyzes the initial step in mitochondrial fatty acid oxidation (FAO). We produced a mouse model of LCAD deficiency with severely impaired FAO. Matings between LCAD +/- mice yielded an abnormally low number of L...

a Nutrition and Consumer Protection Division, Food and Agriculture Organization of the United Nations (FAO), Rome, Italy; b Department of Nutrition for Health and Development, World Health Organization (WHO), Geneva, Switzerland; c Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago, Chile; d Nutrition and Public Health Intervention Research Unit, London ...

* Vinod Ahuja is a faculty member at the Centre for Management in Agriculture, Indian Institute of Management, Ahmedabad. Elizabeth Redmond is a consultant at the Livestock Information, Sector Analysis and Policy Branch, FAO, Rome. This paper was prepared during Vinod Ahuja’s visit to FAO in April-May 2001. We sincerely acknowledge the inputs received from Henning Steinfeld and Joachim Otte on ...

RATIONALE The energy sensor AMP-activated protein kinases (AMPK) is thought to play an important role in regulating myocardial fatty acid oxidation (FAO) via its phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC). However, studies supporting this have not directly assessed whether the maintenance of FAO rates and subsequent cardiac function requires AMPK-dependent inhibitor...

While acknowledging the need to take into account recent scientific developments and, if necessary, to integrate them into nutrition recommendations on carbohydrate intake, CEFS (Comité Européen des Fabricants de Sucre), on behalf of all sugar manufacturers in the EU and Switzerland, can only regret that not all the available scientific evidence was considered by FAO/WHO for that purpose. On th...

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