نتایج جستجو برای: دستگاه فانکشنال fa ii
تعداد نتایج: 626566 فیلتر نتایج به سال:
BACKGROUND Cell migration requires coordinated formation of focal adhesions (FAs) and assembly and contraction of the actin cytoskeleton. Nonmuscle myosin II (MII) is a critical mediator of contractility and FA dynamics in cell migration. Signaling downstream of the small GTPase Rac1 also regulates FA and actin dynamics, but its role in regulation of MII during migration is less clear. RESULT...
During fasting, when overall metabolism changes, the contribution of glucose and fatty acids (FA) to cardiac energy production alters as well. Here, we examined if the heart is able to adapt to such fasting-induced changes by modulation of its gene expression. Rats were fed ad libitum or fasted for 46 h, resulting in reduced circulating glucose levels and a 3-fold rise in FA. Besides changes in...
Fluctuation Analysis (FA) and specially Detrended Fluctuation Analysis (DFA) are techniques commonly used to quantify correlations and scaling properties of complex time series such as the observable outputs of great variety of dynamical systems, from Economics to Physiology. Often, such correlated time series are analyzed using the magnitude and sign decomposition, i.e., by using FA or DFA to ...
Focal adhesions (FAs) undergo maturation that culminates in size and composition changes that modulate adhesion, cytoskeleton remodeling and differentiation. Although it is well recognized that stimuli for osteogenesis of mesenchymal stem cells (MSCs) drive FA maturation, actin organization and stress fiber polarization, the extent to which FA-mediated signals regulated by the FA protein compos...
This study investigated the immunomodulatory effects of ferulic acid (FA) on antigen-presenting dendritic cells (DCs) in vitro and its antiallergic effects against ovalbumin- (OVA-) induced Th2-mediated allergic asthma in mice. The activation of FA-treated bone marrow-derived DCs by lipopolysaccharide (LPS) stimulation induced a high level of interleukin- (IL-) 12 but reduced the expression lev...
تثبیت نیتروژن مولکولی توسط باکتریهای ریزوبیومی، منبع اصلی برای ورود پایدار نیتروژن مورد نیاز گیاهان به سیستمهای کشاورزی است. تثبیت زیستی مولکول نیتروژن در کشاورزی میتواند به وسیله مایهزنی گیاهان لگوم با باکتریهای ریزوبیومی دارای توانایی بالا در تثبیت این مولکول بهبود پیدا کند. آگاهی از تنوع زیستی جمعیتهای بومی این باکتریها برای طراحی تدابیر مایهزنی موفق...
Fanconi anemia (FA) patients have an exacerbated risk of head and neck squamous cell carcinoma (HNSCC). Treatment is challenging as FA display enhanced toxicity to standard treatments, including radio/chemotherapy. Therefore, better therapies well new disease models are urgently needed. We used CRISPR/Cas9 editing tools in order interrupt the human FANCA gene by generation insertions/deletions ...
Recordings from single peripheral nerve fibres made it possible to analyse the functional properties of tactile afferent units supplying the glabrous skin of the human hand and to assess directly the relation between impulse discharge and perceptive experiences. The 17,000 tactile units in this skin area of the human hand are of four different types: two fast adapting types, FA I and FA II (for...
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