In vitro models of granulopoiesis involving the inducible expression of either CCAAT enhancer binding protein alpha (C/EBP ) or C/EBP in myeloid cells have been shown to lead to the induction of a granulocytic maturation program accompanied by the expression of myeloidspecific genes. Since members of the C/EBP family of transcription factors recognize and bind to similar DNA-binding motifs, it ...

AIMS Elevated blood pressure (EBP) is the most prevalent and potentially modifiable risk factor for AF, yet little is known of its atrial effects. We aimed to characterize the atrial electrical and structural changes in a chronic ovine model of EBP after prenatal corticosteroid exposure. METHODS AND RESULTS Twelve sheep with chronically EBP (mean arterial pressure 94+/-3 mmHg) and six control...

Immunomodulatory derivatives of thalidomide (IMiD compounds), such as pomalidomide and lenalidomide, are highly active in multiple myeloma (MM) treatment. However, the precise mechanisms of action and resistance in MM are unresolved. Here we show that IMiD compounds down-regulate CCAAT/enhancer-binding protein(C/EBP ) resulting in abrogation of cell proliferation. Overexpression of C/EBP rescue...

OBJECTIVE The main purpose of this study was to describe a group of Colombian physical therapists' beliefs and attitudes towards Evidence-Based Practice (EBP), their education, knowledge and skills for implementing EBP, the use of relevant literature in clinical practice, access to and availability of scientific information and perceived barriers to including EBP in practice. METHODS This was...

Expression of the alpha-1 acid glycoprotein (AGP) gene (agp) is activated by a key transcription factor, AGP/enhancer-binding protein (AGP/EBP, commonly called C/EBP beta), in the liver during the acute-phase response. In addition to this positive regulation, agp is negatively regulated by nucleolin (T. H. Yang et al., Mol. Cell. Biol. 14:6068-6074, 1994). Other factors involve in positive regu...

Evidence-based practice (EBP) has emerged as a marker for health care quality. However, several barriers prevent the transition of nursing research to practice, such as lack of knowledge, lack of time, and little perceived value. The purpose of this descriptive study was to examine the extent of current understanding of EBP, knowledge/skills, and attitudes among registered nurses in an urban Mi...

Background: Students often have difficulty engaging with evidenced-based practice (EBP) courses that are largely theoretical and lack clinical relevance. This may result in graduates lacking vital skills to critique participate quality improvement. Approach: paper describes the development implementation of a collaborative academic healthcare industry-based course linked aspects EBP. undertook ...

The integration of evidence-based practice (EBP) in human service organizations has increased during the last decade. Providing best possible treatment by applying research and considering client’s specific needs, EBP is recommended for organizations. However, due to its oftentimes manual-based format, critics claim that a result focus on cost-efficiency, control, standardization work. Differen...

Background: Despite the emergence and development of evidence-based practice (EBP) in recent years, its adoption continues to be limited. This study used Rogers's diffusion of innovation theory to identify the factors that advance EBP adoption, determine the process by which such adoption occurs, and develop an EBP adoption model. Methods: This descriptive correlational study with model testing...

قدرت تفکیک دستگاه طیف‌نگار جرمی به صورت مستقیم شدت یون خروجی و انرژی آن بستگی دارد. مقدار تولید شده جریان باریکه الکترونی وابسته است. از جمله وظایف مدار کنترل چشمه برخورد تنظیم برای رسیدن بهینه می‌باشد. در ساخت پارامترهایی نظیر تثبیت آن، دقیق پتانسل الکتریکی لنز الکترودهای یونی بسیار حایز اهمیت این مقاله با قابلیت انتشار الکترون، پتانسیل نقاط طراحی ساخته شد. کنترلر بر روی طیف نگار 44Varian MAT ...